Resources

This page allows access to all of our drug sensitivity data and the genomic datasets used in our analyses.

Data File Download Tool

Data Files

Data Class Data Type Objects Brief description (with links) Details Last updated
Annotated Reference Cell lines Annotated list of Cell lines List of Cell lines included in the study with molecular and drug-response data availability, microsatellite instability status, growth properties and media, TCGA and COSMIC tissue classification July 4th 2016
Annotated Reference Drugs Screened compounds List of screened drugs including targets, targeted process/pathways, clinical stage July 4th 2016
Annotated Reference Cell lines Shared cell lines and drugs (GDSC, CCLE & CTRP) To aid comparison we list the cell lines and drugs within the GDSC study that are also in the CCLE (Barretina et al, Nature 2012) and/or CTRP (Seashore-Ludlow et al, Cancer Discovery 2015) studies July 4th 2016
Copy number Raw Cell lines Copy number data for Cell lines Affymetrix SNP6 cel files at EGA (EGAS00001000978) July 4th 2016
Copy number Preprocessed Cell lines Gene level copy number data Copy number data for all genes across all samples derived from PICNIC analysis of Affymetrix SNP6 segmentation data (available via COSMIC Cell Lines Project) July 4th 2016
Copy number Preprocessed Cell lines RACS in cell lines Recurrently altered chromosomal segments in cell lines identified from the analysis of patient tumours. As described in Iorio F, et al. Cell. 2016 July 4th 2016
Copy number Preprocessed Cell lines RACSs CNV BEMs for cell lines Binary event matrix with status in cell lines of recurrently altered chromosomal segments (RACS) identified from the analysis of patient tumours. As described in Iorio F, et al. Cell. 2016. July 4th 2016
Drug Raw Cell lines Drugs compound sensitivity data for Cell lines GDSC drug screening data July 4th 2016
Drug Preprocessed Cell lines/Drugs log(IC50) and AUC values Natural log half maximal inhibitory concentration (IC50) and Area under the dose-response curve (AUCs) values for all screened cell line/drug combinations July 4th 2016
Drug Preprocessed Cell lines/Drugs ANOVA results Results from Pan-Cancer and cancer specific ANOVA July 4th 2016
Expression Raw Cell lines Expression array data for Cell lines Affymetrix Human Genome U219 array data at ArrayExpress (E-MTAB-3610) July 4th 2016
Expression Preprocessed Cell lines RMA normalised expression data for Cell lines RMA normalised basal expression profiles for all the Cell lines July 4th 2016
Methylation Raw Cell lines DNA methylation data for Cell lines IlluminaHumanMethylation450 BeadChip data at GEO (GSE68379) July 4th 2016
Sequencing Raw Cell lines WES data for Cell lines Illumina HiSeq 2000 Whole exome sequence BAM files at EGA (EGAS00001000978) July 4th 2016
Sequencing Preprocessed Cell lines Cell-line sequence variants List of genomic variants found in Cell lines by whole exome sequencing July 4th 2016
Sequencing Preprocessed Cell lines Sequencing BEMs for Cell lines Binary event matrix with status in cell lines of selected cancer genes identified from the analysis of patient tumours. As described in Iorio F, et al. Cell. 2016. July 4th 2016

Results of data analysis (from 'A landscape of pharmacogenomic interactions in cancer', Iorio F et al. Cell. 2016)

Click here to navigate linked webpages to access data and results associated with our publication "A landscape of Pharmacogenomic Interations in Cancer". We provide these as a resource but for our most current please access data through the GDSC website.

Archive

Click here to download all releases.

Contact us | Cookies policy | Terms & Conditions. This site is hosted by the Wellcome Trust Sanger Institute.