Drugs

For this analysis we have correlated drug sensitivity data with genomic datasets to identify molecular features associated with drug sensitivity and resistance.

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Legacy

Name	Synonyms	Targets	PubCHEM	Sample size	Last updated
17-AAG	17-AAG	HSP90	6505803	574	14-MAY-12
681640	681640	WEE1, CHK1	10384072	541	14-MAY-12
A-443654	KIN001-139	AKT1/2/3	10172943	359	16-MAR-12
A-769662		AMPK agonist	11360391	668	26-MAR-12
A-770041	A770041,KIN001-111	SRC family	9549184	360	16-MAR-12
ABT-263		BCL2, BCL-XL, BCL-W	24978538	561	14-MAY-12
ABT-888	ABT-888	PARP1/2	11960529	575	14-MAY-12
AG-014699	PF-01367338	PARP1, PARP2	9931953	480	14-MAY-12
AICAR	N1-(b-D-Ribofuranosyl)-5-aminoimidazole-4-carboxamide	AMPK agonist	65110	563	14-MAY-12
AKT inhibitor VIII		AKT1/2	16218954	668	26-MAR-12
AMG-706	AMG-706	VEGFR, RET, c-KIT, PDGFR	11667893	561	14-MAY-12
AP-24534	AP24534 (KIN001-192)	ABL	24826799	668	26-MAR-12
AS601245	AS601245	JNK	11422035	662	26-MAR-12
ATRA	Tretinoin	Retinoic acid and retinoid X receptor agonist	444795	574	14-MAY-12
AUY922	VER-52296,NVP-AUY922	HSP90	10096043	662	26-MAR-12
AZ628		BRAF	11676786	355	16-MAR-12
AZD-0530	Saracatinib,KIN001-045	SRC, ABL1	10302451	362	16-MAR-12
AZD-2281	KU-0059436, Olaparib	PARP1/2	23725625	558	14-MAY-12
AZD6244		MEK1/2	10127622	531	14-MAY-12
AZD6482	AZD6482 (KIN001-193)	PI3Kb (P3C2B)	44137675	668	26-MAR-12
AZD7762	AZD 7762	CHK1/2		575	14-MAY-12
AZD8055	AZD8055	mTORC1/2		554	14-MAY-12
Axitinib	AG-013736	PDGFR, KIT, VEGFR	6450551	577	14-MAY-12
BAY 61-3606		SYK	16760671	662	26-MAR-12
BI-2536	KIN001-124	PLK1/2/3	11364421	360	16-MAR-12
BI-D1870	BI-D1870	RSK1/2/3/5, PLK1, AURKB	25023738	574	14-MAY-12
BIBW2992	Tovok, Afatinib	EGFR, ERBB2	10184653	577	14-MAY-12
BIRB 0796		p38, JNK2	156422	574	14-MAY-12
BMS-509744	KIN001-127	ITK	20635522	360	16-MAR-12
BMS-536924	KIN001-126	IGF1R	10390396	360	16-MAR-12
BMS-708163	Avagacestat	gamma-secretase	46883536	483	14-MAY-12
BMS-754807		IGF1R	24785538	662	26-MAR-12
BX-795	BX 795	TBK1, PDK1, IKK, AURKB/C	10077147	539	14-MAY-12
Bexarotene	LG-100069,LGD-1069	Retinioic acid X family agonist	82146	662	26-MAR-12
Bicalutamide	ICI-176334	Androgen receptor (ANDR)	2375	662	26-MAR-12
Bleomycin		DNA damage	5460769	662	26-MAR-12
Bortezomib	LDP-341,PS-341	Proteasome	387447	355	16-MAR-12
Bosutinib	SKI-606	SRC, ABL, TEC	5328940	575	14-MAY-12
Bryostatin 1	Bryostatin 1	PRKC	5280757	662	26-MAR-12
CCT007093		PPM1D		483	14-MAY-12
CCT018159		HSP90		471	30-APR-12
CEP-701	CEP-701	FLT3, JAK2, NTRK1, RET	126565	577	14-MAY-12
CGP-082996	CINK4,KIN001-021	CDK4	24825971	359	16-MAR-12
CGP-60474	KIN001-019	CDK1/2/5/7/9	644215	359	16-MAR-12
CHIR-99021	CT 99021	GSK3B	9956119	668	26-MAR-12
CI-1040	PD-18435,PD-184352	MEK1/2	6918454	574	30-APR-12
CMK	KIN001-128	RSK	NO MATCH	359	16-MAR-12
Camptothecin	7-Ethyl-10-Hydroxy-Camptothecin,SN-38	TOP1	104842	577	14-MAY-12
Cisplatin	cis-Diammineplatinum(II) dichloride	DNA crosslinker	84691	577	14-MAY-12
Cyclopamine	11-deoxojervine	SMO	442972	355	16-MAR-12
Cytarabine	Ara-Cytidine,Arabinosyl Cytosine,U-19920	DNA synthesis	6253	577	14-MAY-12
DMOG	Dimethyloxalylglcine	Prolyl-4-Hydroxylase	560326	668	26-MAR-12
Dasatinib	KIN001-005	ABL, SRC, KIT, PDGFR	3062316	359	16-MAR-12
Docetaxel	RP-56976	Microtubules	148124	568	14-MAY-12
Doxorubicin	Doxil,Rubex	DNA intercalating	31703	662	26-MAR-12
EHT 1864		Rac GTPases		483	14-MAY-12
Elesclomol		HSP70		577	14-MAY-12
Embelin		XIAP	3218	662	26-MAR-12
Epothilone B	GNF-PF-193	Microtubules	448013	662	26-MAR-12
Erlotinib		EGFR	176870	329	16-MAR-12
Etoposide		TOP2	36462	668	26-MAR-12
FH535	FH535	unknown	3463933	662	26-MAR-12
FTI-277		Farnesyl transferase (FNTA)	3005532	668	26-MAR-12
GDC-0449		SMO	24776445	564	14-MAY-12
GDC0941		PI3K (class 1)	17755052	532	14-MAY-12
GNF-2	KIN001-013 (GNF-2 / 3-(6-(4-(trifluoromethoxy)phenylamino)pyrimidin-4-yl)benzamide)	BCR-ABL	5311510	359	16-MAR-12
GSK-650394		SGK3	25022668	662	26-MAR-12
GSK269962A	KIN001-155	ROCK	16095342	358	16-MAR-12
GW 441756		NTRK1		577	14-MAY-12
GW843682X	KIN001-134	PLK1	15983966	360	16-MAR-12
Gefitinib	ZD-1839	EGFR	123631	577	14-MAY-12
Gemcitabine	Gemzar, LY-188011	DNA replication	60750	662	26-MAR-12
IPA-3	IPA-3	PAK	521106	662	26-MAR-12
Imatinib	Gleevec,STI-571	ABL, KIT, PDGFR	5291	362	16-MAR-12
JNJ-26854165		MDM2	11609586	480	14-MAY-12
JNK Inhibitor VIII	JNK Inhibitor VIII	JNK	11624601	574	14-MAY-12
JNK-9L	KIN001-204	JNK	NO MATCH	668	26-MAR-12
JW-7-52-1		MTOR	49836027	360	16-MAR-12
KIN001-135	KIN001-135	IKKE	11626927	359	16-MAR-12
KU-55933		ATM	5278396	552	14-MAY-12
LFM-A13	DDE-28	BTK	9549280	662	26-MAR-12
Lapatinib		EGFR, ERBB2	208908	352	16-MAR-12
Lenalidomide		TNF alpha	216326	577	14-MAY-12
MG-132	zLLL	Proteasome	462382	358	16-MAR-12
MK-2206		AKT1/2		531	14-MAY-12
MS-275	MS275	HDAC	4261	355	16-MAR-12
Metformin	1,1-Dimethylbiguanide hydrochloride	AMPK agonist	4091	576	14-MAY-12
Methotrexate		Dihydrofolate reductase (DHFR)	126941	545	14-MAY-12
Midostaurin	PKC 412	KIT	24202429	668	26-MAR-12
Mitomycin C	Mytozytrex,NSC-26980	DNA crosslinker	5746	662	26-MAR-12
NSC-87877		SHP1/2 (PTN6/11)	5459322	668	26-MAR-12
NU-7441	NU-7432,KU-57788	DNAPK	11327430	552	14-MAY-12
NVP-BEZ235	BEZ235	PI3K (Class 1) and mTORC1/2		552	14-MAY-12
NVP-TAE684	KIN001-017	ALK	16038120	362	16-MAR-12
Nilotinib		ABL	644241	577	14-MAY-12
Nutlin-3a	Nutlin-3a (-) enantiomer	MDM2	11433190	561	14-MAY-12
OSI-906	OSI-906	IFG1R	11640390	662	26-MAR-12
Obatoclax Mesylate		BCL-2, BCL-XL, MCL-1	16727411	662	26-MAR-12
PAC-1	PAC-1	CASP3 activator	6851947	662	26-MAR-12
PD-0325901	PD-0325901	MEK1/2	9826528	554	14-MAY-12
PD-0332991	PD-0332991	CDK4/6	5330286	531	14-MAY-12
PD-173074	PD-173074	FGFR1/3	1401	561	14-MAY-12
PF-02341066	Crizotinib,KIN001-023	MET, ALK	11496366	362	16-MAR-12
PF-4708671		p70 S6KA		480	14-MAY-12
PF-562271	(KIN001-205)	FAK	11713159	668	26-MAR-12
PHA-665752		MET	10461815	362	16-MAR-12
PLX4720		BRAF	24180719	572	14-MAY-12
Paclitaxel	BMS-181339-01	Microtubules	36314	360	16-MAR-12
Parthenolide		NFKB1	5420805	359	16-MAR-12
Pazopanib	GW786034	VEGFR, PDGFRA, PDGFRB, KIT	10113978	662	26-MAR-12
Pyrimethamine		Dihydrofolate reductase (DHFR)	4993	358	16-MAR-12
QS11	QS11	ARFGAP	No Match	662	26-MAR-12
RDEA119	RDEA119	MEK1/2	44182295	554	14-MAY-12
RO-3306		CDK1	44450571	561	14-MAY-12
Rapamycin	AY-22989,Sirolimus,WY-090217	MTOR	5284616	362	16-MAR-12
Roscovitine	Seliciclib	CDKs	160355	352	16-MAR-12
S-Trityl-L-cysteine	NSC 83265	KIF11	76044	359	16-MAR-12
SB 216763	SB 216763	GSK3A/B		558	30-APR-12
SB590885		BRAF	11316960	541	14-MAY-12
SL 0101-1		RSK, AURKB, PIM3		570	30-APR-12
Salubrinal	3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide	GADD34-PP1C phosphatase	5717801	356	16-MAR-12
Shikonin	Shikonin	unknown	5208	668	26-MAR-12
Sorafenib	BAY-43-9006,Nexavar	PDGFRA, PDGFRB, KDR, KIT, FLT3	216239	358	16-MAR-12
Sunitinib	Sutent	PDGFRA, PDGFRB, KDR, KIT, FLT3	5329102	359	16-MAR-12
TW 37		BCL-2, BCL-XL	11455910	480	14-MAY-12
Temsirolimus	CCI-779	MTOR	6918289	577	14-MAY-12
Thapsigargin		ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	446378	662	26-MAR-12
Tipifarnib		Farnesyl-transferase (FNTA)	159324	662	26-MAR-12
VX-680	MK-045,MK-0457,VX-68	Aurora A/B/C, FLT3, ABL1, JAK2,	5494449	359	16-MAR-12
VX-702		p38	10341154	574	14-MAY-12
Vinblastine	Vinblastine sulphate	Microtubules	6710780	577	14-MAY-12
Vinorelbine		Microtubules	60780	668	26-MAR-12
Vorinostat	SAHA	HDAC inhibitor Class I, IIa, IIb, IV	5311	558	14-MAY-12
WH-4-023	KIN001-112	SRC family, ABL	11844351	359	16-MAR-12
WO2009093972	AZD6482	PI3Kb		469	14-MAY-12
WZ-1-84	KIN001-123	BMX	49821040	359	16-MAR-12
XMD8-85	XMD8-85	ERK5 (MK07)	46844147	355	16-MAR-12
Z-LLNle-CHO	Z-L-Norleucine-CHO	g-secretase	16760646	359	16-MAR-12
ZM-447439	ZM447439	AURKB	9914412	561	14-MAY-12

Name	Synonyms	Targets	PubCHEM	Sample size	Last updated
A-443654	KIN001-139	AKT1/2/3	10172943	359	16-MAR-12
A-769662		AMPK agonist	11360391	668	26-MAR-12
A-770041	A770041,KIN001-111	SRC family	9549184	360	16-MAR-12
ABT-263		BCL2, BCL-XL, BCL-W	24978538	561	14-MAY-12
ABT-888	ABT-888	PARP1/2	11960529	575	14-MAY-12
AG-014699	PF-01367338	PARP1, PARP2	9931953	480	14-MAY-12
AICAR	N1-(b-D-Ribofuranosyl)-5-aminoimidazole-4-carboxamide	AMPK agonist	65110	563	14-MAY-12
AKT inhibitor VIII		AKT1/2	16218954	668	26-MAR-12
AMG-706	AMG-706	VEGFR, RET, c-KIT, PDGFR	11667893	561	14-MAY-12
AP-24534	AP24534 (KIN001-192)	ABL	24826799	668	26-MAR-12
AS601245	AS601245	JNK	11422035	662	26-MAR-12
ATRA	Tretinoin	Retinoic acid and retinoid X receptor agonist	444795	574	14-MAY-12
AUY922	VER-52296,NVP-AUY922	HSP90	10096043	662	26-MAR-12
AZ628		BRAF	11676786	355	16-MAR-12
AZD-0530	Saracatinib,KIN001-045	SRC, ABL1	10302451	362	16-MAR-12
AZD-2281	KU-0059436, Olaparib	PARP1/2	23725625	558	14-MAY-12
AZD6244		MEK1/2	10127622	531	14-MAY-12
AZD6482	AZD6482 (KIN001-193)	PI3Kb (P3C2B)	44137675	668	26-MAR-12
AZD7762	AZD 7762	CHK1/2		575	14-MAY-12
AZD8055	AZD8055	mTORC1/2		554	14-MAY-12
Axitinib	AG-013736	PDGFR, KIT, VEGFR	6450551	577	14-MAY-12

Name	Synonyms	Targets	PubCHEM	Sample size	Last updated
BAY 61-3606		SYK	16760671	662	26-MAR-12
BI-2536	KIN001-124	PLK1/2/3	11364421	360	16-MAR-12
BI-D1870	BI-D1870	RSK1/2/3/5, PLK1, AURKB	25023738	574	14-MAY-12
BIBW2992	Tovok, Afatinib	EGFR, ERBB2	10184653	577	14-MAY-12
BIRB 0796		p38, JNK2	156422	574	14-MAY-12
BMS-509744	KIN001-127	ITK	20635522	360	16-MAR-12
BMS-536924	KIN001-126	IGF1R	10390396	360	16-MAR-12
BMS-708163	Avagacestat	gamma-secretase	46883536	483	14-MAY-12
BMS-754807		IGF1R	24785538	662	26-MAR-12
BX-795	BX 795	TBK1, PDK1, IKK, AURKB/C	10077147	539	14-MAY-12
Bexarotene	LG-100069,LGD-1069	Retinioic acid X family agonist	82146	662	26-MAR-12
Bicalutamide	ICI-176334	Androgen receptor (ANDR)	2375	662	26-MAR-12
Bleomycin		DNA damage	5460769	662	26-MAR-12
Bortezomib	LDP-341,PS-341	Proteasome	387447	355	16-MAR-12
Bosutinib	SKI-606	SRC, ABL, TEC	5328940	575	14-MAY-12
Bryostatin 1	Bryostatin 1	PRKC	5280757	662	26-MAR-12

Name	Synonyms	Targets	PubCHEM	Sample size	Last updated
CCT007093		PPM1D		483	14-MAY-12
CCT018159		HSP90		471	30-APR-12
CEP-701	CEP-701	FLT3, JAK2, NTRK1, RET	126565	577	14-MAY-12
CGP-082996	CINK4,KIN001-021	CDK4	24825971	359	16-MAR-12
CGP-60474	KIN001-019	CDK1/2/5/7/9	644215	359	16-MAR-12
CHIR-99021	CT 99021	GSK3B	9956119	668	26-MAR-12
CI-1040	PD-18435,PD-184352	MEK1/2	6918454	574	30-APR-12
CMK	KIN001-128	RSK	NO MATCH	359	16-MAR-12
Camptothecin	7-Ethyl-10-Hydroxy-Camptothecin,SN-38	TOP1	104842	577	14-MAY-12
Cisplatin	cis-Diammineplatinum(II) dichloride	DNA crosslinker	84691	577	14-MAY-12
Cyclopamine	11-deoxojervine	SMO	442972	355	16-MAR-12
Cytarabine	Ara-Cytidine,Arabinosyl Cytosine,U-19920	DNA synthesis	6253	577	14-MAY-12

Name	Synonyms	Targets	PubCHEM	Sample size	Last updated
DMOG	Dimethyloxalylglcine	Prolyl-4-Hydroxylase	560326	668	26-MAR-12
Dasatinib	KIN001-005	ABL, SRC, KIT, PDGFR	3062316	359	16-MAR-12
Docetaxel	RP-56976	Microtubules	148124	568	14-MAY-12
Doxorubicin	Doxil,Rubex	DNA intercalating	31703	662	26-MAR-12

Name	Synonyms	Targets	PubCHEM	Sample size	Last updated
EHT 1864		Rac GTPases		483	14-MAY-12
Elesclomol		HSP70		577	14-MAY-12
Embelin		XIAP	3218	662	26-MAR-12
Epothilone B	GNF-PF-193	Microtubules	448013	662	26-MAR-12
Erlotinib		EGFR	176870	329	16-MAR-12
Etoposide		TOP2	36462	668	26-MAR-12

Name	Synonyms	Targets	PubCHEM	Sample size	Last updated
FH535	FH535	unknown	3463933	662	26-MAR-12
FTI-277		Farnesyl transferase (FNTA)	3005532	668	26-MAR-12

Name	Synonyms	Targets	PubCHEM	Sample size	Last updated
GDC-0449		SMO	24776445	564	14-MAY-12
GDC0941		PI3K (class 1)	17755052	532	14-MAY-12
GNF-2	KIN001-013 (GNF-2 / 3-(6-(4-(trifluoromethoxy)phenylamino)pyrimidin-4-yl)benzamide)	BCR-ABL	5311510	359	16-MAR-12
GSK-650394		SGK3	25022668	662	26-MAR-12
GSK269962A	KIN001-155	ROCK	16095342	358	16-MAR-12
GW 441756		NTRK1		577	14-MAY-12
GW843682X	KIN001-134	PLK1	15983966	360	16-MAR-12
Gefitinib	ZD-1839	EGFR	123631	577	14-MAY-12
Gemcitabine	Gemzar, LY-188011	DNA replication	60750	662	26-MAR-12

No drugs in list

Name	Synonyms	Targets	PubCHEM	Sample size	Last updated
IPA-3	IPA-3	PAK	521106	662	26-MAR-12
Imatinib	Gleevec,STI-571	ABL, KIT, PDGFR	5291	362	16-MAR-12

Name	Synonyms	Targets	PubCHEM	Sample size	Last updated
JNJ-26854165		MDM2	11609586	480	14-MAY-12
JNK Inhibitor VIII	JNK Inhibitor VIII	JNK	11624601	574	14-MAY-12
JNK-9L	KIN001-204	JNK	NO MATCH	668	26-MAR-12
JW-7-52-1		MTOR	49836027	360	16-MAR-12

Name	Synonyms	Targets	PubCHEM	Sample size	Last updated
KIN001-135	KIN001-135	IKKE	11626927	359	16-MAR-12
KU-55933		ATM	5278396	552	14-MAY-12

Name	Synonyms	Targets	PubCHEM	Sample size	Last updated
LFM-A13	DDE-28	BTK	9549280	662	26-MAR-12
Lapatinib		EGFR, ERBB2	208908	352	16-MAR-12
Lenalidomide		TNF alpha	216326	577	14-MAY-12

Name	Synonyms	Targets	PubCHEM	Sample size	Last updated
MG-132	zLLL	Proteasome	462382	358	16-MAR-12
MK-2206		AKT1/2		531	14-MAY-12
MS-275	MS275	HDAC	4261	355	16-MAR-12
Metformin	1,1-Dimethylbiguanide hydrochloride	AMPK agonist	4091	576	14-MAY-12
Methotrexate		Dihydrofolate reductase (DHFR)	126941	545	14-MAY-12
Midostaurin	PKC 412	KIT	24202429	668	26-MAR-12
Mitomycin C	Mytozytrex,NSC-26980	DNA crosslinker	5746	662	26-MAR-12

Name	Synonyms	Targets	PubCHEM	Sample size	Last updated
NSC-87877		SHP1/2 (PTN6/11)	5459322	668	26-MAR-12
NU-7441	NU-7432,KU-57788	DNAPK	11327430	552	14-MAY-12
NVP-BEZ235	BEZ235	PI3K (Class 1) and mTORC1/2		552	14-MAY-12
NVP-TAE684	KIN001-017	ALK	16038120	362	16-MAR-12
Nilotinib		ABL	644241	577	14-MAY-12
Nutlin-3a	Nutlin-3a (-) enantiomer	MDM2	11433190	561	14-MAY-12

Name	Synonyms	Targets	PubCHEM	Sample size	Last updated
OSI-906	OSI-906	IFG1R	11640390	662	26-MAR-12
Obatoclax Mesylate		BCL-2, BCL-XL, MCL-1	16727411	662	26-MAR-12

Name	Synonyms	Targets	PubCHEM	Sample size	Last updated
PAC-1	PAC-1	CASP3 activator	6851947	662	26-MAR-12
PD-0325901	PD-0325901	MEK1/2	9826528	554	14-MAY-12
PD-0332991	PD-0332991	CDK4/6	5330286	531	14-MAY-12
PD-173074	PD-173074	FGFR1/3	1401	561	14-MAY-12
PF-02341066	Crizotinib,KIN001-023	MET, ALK	11496366	362	16-MAR-12
PF-4708671		p70 S6KA		480	14-MAY-12
PF-562271	(KIN001-205)	FAK	11713159	668	26-MAR-12
PHA-665752		MET	10461815	362	16-MAR-12
PLX4720		BRAF	24180719	572	14-MAY-12
Paclitaxel	BMS-181339-01	Microtubules	36314	360	16-MAR-12
Parthenolide		NFKB1	5420805	359	16-MAR-12
Pazopanib	GW786034	VEGFR, PDGFRA, PDGFRB, KIT	10113978	662	26-MAR-12
Pyrimethamine		Dihydrofolate reductase (DHFR)	4993	358	16-MAR-12

Name	Synonyms	Targets	PubCHEM	Sample size	Last updated
QS11	QS11	ARFGAP	No Match	662	26-MAR-12

Name	Synonyms	Targets	PubCHEM	Sample size	Last updated
RDEA119	RDEA119	MEK1/2	44182295	554	14-MAY-12
RO-3306		CDK1	44450571	561	14-MAY-12
Rapamycin	AY-22989,Sirolimus,WY-090217	MTOR	5284616	362	16-MAR-12
Roscovitine	Seliciclib	CDKs	160355	352	16-MAR-12

Name	Synonyms	Targets	PubCHEM	Sample size	Last updated
S-Trityl-L-cysteine	NSC 83265	KIF11	76044	359	16-MAR-12
SB 216763	SB 216763	GSK3A/B		558	30-APR-12
SB590885		BRAF	11316960	541	14-MAY-12
SL 0101-1		RSK, AURKB, PIM3		570	30-APR-12
Salubrinal	3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide	GADD34-PP1C phosphatase	5717801	356	16-MAR-12
Shikonin	Shikonin	unknown	5208	668	26-MAR-12
Sorafenib	BAY-43-9006,Nexavar	PDGFRA, PDGFRB, KDR, KIT, FLT3	216239	358	16-MAR-12
Sunitinib	Sutent	PDGFRA, PDGFRB, KDR, KIT, FLT3	5329102	359	16-MAR-12

Name	Synonyms	Targets	PubCHEM	Sample size	Last updated
TW 37		BCL-2, BCL-XL	11455910	480	14-MAY-12
Temsirolimus	CCI-779	MTOR	6918289	577	14-MAY-12
Thapsigargin		ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	446378	662	26-MAR-12
Tipifarnib		Farnesyl-transferase (FNTA)	159324	662	26-MAR-12

No drugs in list

Name	Synonyms	Targets	PubCHEM	Sample size	Last updated
VX-680	MK-045,MK-0457,VX-68	Aurora A/B/C, FLT3, ABL1, JAK2,	5494449	359	16-MAR-12
VX-702		p38	10341154	574	14-MAY-12
Vinblastine	Vinblastine sulphate	Microtubules	6710780	577	14-MAY-12
Vinorelbine		Microtubules	60780	668	26-MAR-12
Vorinostat	SAHA	HDAC inhibitor Class I, IIa, IIb, IV	5311	558	14-MAY-12

Name	Synonyms	Targets	PubCHEM	Sample size	Last updated
WH-4-023	KIN001-112	SRC family, ABL	11844351	359	16-MAR-12
WO2009093972	AZD6482	PI3Kb		469	14-MAY-12
WZ-1-84	KIN001-123	BMX	49821040	359	16-MAR-12

Name	Synonyms	Targets	PubCHEM	Sample size	Last updated
XMD8-85	XMD8-85	ERK5 (MK07)	46844147	355	16-MAR-12

No drugs in list

Name	Synonyms	Targets	PubCHEM	Sample size	Last updated
Z-LLNle-CHO	Z-L-Norleucine-CHO	g-secretase	16760646	359	16-MAR-12
ZM-447439	ZM447439	AURKB	9914412	561	14-MAY-12

Name	Synonyms	Targets	PubCHEM	Sample size	Last updated
17-AAG	17-AAG	HSP90	6505803	574	14-MAY-12
681640	681640	WEE1, CHK1	10384072	541	14-MAY-12

Legacy genes

These web pages contain an older drug sensitivity dataset that is separate from our main screening dataset. These data were generated using a different screening format (McDermott et al, PNAS December 11, 2007 vol. 104 no. 50 19936-19941) and are maintained as a resource but are not updated with new data or analyses. In many instances new datasets have been generated for these compounds and are available.

Name	Conc Range(uM)	Putative Target(s)	Source	Sample Size	Last Updated
Erlotinib	0-2	EGFR	Academic collaboration	352	14/03/10
Rapamycin	0-10	MTOR	Calbiochem	352	14/03/10
Sunitinib	0-10	PDGFRA, KIT, FLT3	Pfizer	352	14/03/10
PHA665752	0-1	MET	Pfizer	352	14/03/10
MG-132	0-1	[26S proteasome]	Calbiochem	352	14/03/10
Paclitaxel	0-0.1	[ß subunit of tubulin]	LKT Laboratories	352	14/03/10
HKI-272	0-2	EGFR, ERBB2	Wyeth	352	14/03/10
Cyclopamine	0-10	SMO	LKT Laboratories	352	14/03/10
Gö 6976	0-10	PRKCA, PRKCB	Calbiochem	352	14/03/10
Geldanamycin	0-1	HSP90AA1, HSP90AB1	LKT Laboratories	352	14/03/10
AZ628	0-2	BRAF, RAF1	AstraZeneca	352	14/03/10
Sorafenib	0-2	PDGFRA, KIT, KDR, FLT3	LC Laboratories	350	14/03/10
MK-0457	0-2	AURKA, AURKB, AURKC, ABL1	Academic collaboration	350	14/03/10
Imatinib	0-2	ABL1, KIT, PDGFRA	Academic collaboration	350	14/03/10
TAE684	0-2	ALK	Academic collaboration	350	14/03/10
PD173074	0-2	FGFR1, FGFR3	Calbiochem	350	14/03/10
PF-2341066	0-2	MET, ALK	Academic collaboration	350	14/03/10
AZD0530	0-2	SRC	Academic collaboration	350	14/03/10