Drugs

For this analysis we have correlated drug sensitivity data with genomic datasets to identify molecular features associated with drug sensitivity and resistance.

Name Synonyms Targets PubCHEM Sample size Last screening date
17-AAG 17-AAG HSP90 6505803 574 14-MAY-12
681640 681640 WEE1, CHK1 10384072 541 14-MAY-12
A-443654 KIN001-139 AKT1/2/3 10172943 359 16-MAR-12
A-770041 A770041,KIN001-111 SRC family 9549184 360 16-MAR-12
ABT-263   BCL2, BCL-XL, BCL-W 24978538 561 14-MAY-12
ABT-888 ABT-888 PARP1/2 11960529 575 14-MAY-12
AG-014699 PF-01367338 PARP1, PARP2 9931953 480 14-MAY-12
AICAR N1-(b-D-Ribofuranosyl)-5-aminoimidazole-4-carboxamide AMPK agonist 65110 563 14-MAY-12
AKT inhibitor VIII   AKT1/2 16218954 668 26-MAR-12
AMG-706 AMG-706 VEGFR, RET, c-KIT, PDGFR 11667893 561 14-MAY-12
AP-24534 AP24534 (KIN001-192) ABL 24826799 668 26-MAR-12
AS601245 AS601245 JNK 11422035 662 26-MAR-12
ATRA Tretinoin Retinoic acid and retinoid X receptor agonist 444795 574 14-MAY-12
AUY922 VER-52296,NVP-AUY922 HSP90 10096043 662 26-MAR-12
AZ628   BRAF 11676786 355 16-MAR-12
AZD-0530 Saracatinib,KIN001-045 SRC, ABL1 10302451 362 16-MAR-12
AZD-2281 KU-0059436, Olaparib PARP1/2 23725625 558 14-MAY-12
AZD6244   MEK1/2 10127622 531 14-MAY-12
AZD6482 AZD6482 (KIN001-193) PI3Kb (P3C2B) 44137675 668 26-MAR-12
AZD7762 AZD 7762 CHK1/2   575 14-MAY-12
AZD8055 AZD8055 mTORC1/2   554 14-MAY-12
Axitinib AG-013736 PDGFR, KIT, VEGFR 6450551 577 14-MAY-12
BAY 61-3606   SYK 16760671 662 26-MAR-12
BI-2536 KIN001-124 PLK1/2/3 11364421 360 16-MAR-12
BI-D1870 BI-D1870 RSK1/2/3/5, PLK1, AURKB 25023738 574 14-MAY-12
BIBW2992 Tovok, Afatinib EGFR, ERBB2 10184653 577 14-MAY-12
BIRB 0796   p38, JNK2 156422 574 14-MAY-12
BMS-509744 KIN001-127 ITK 20635522 360 16-MAR-12
BMS-536924 KIN001-126 IGF1R 10390396 360 16-MAR-12
BMS-708163 Avagacestat gamma-secretase 46883536 483 14-MAY-12
BMS-754807   IGF1R 24785538 662 26-MAR-12
BX-795 BX 795 TBK1, PDK1, IKK, AURKB/C 10077147 539 14-MAY-12
Bexarotene LG-100069,LGD-1069 Retinioic acid X family agonist 82146 662 26-MAR-12
Bicalutamide ICI-176334 Androgen receptor (ANDR) 2375 662 26-MAR-12
Bleomycin   DNA damage 5460769 662 26-MAR-12
Bortezomib LDP-341,PS-341 Proteasome 387447 355 16-MAR-12
Bosutinib SKI-606 SRC, ABL, TEC 5328940 575 14-MAY-12
Bryostatin 1 Bryostatin 1 PRKC 5280757 662 26-MAR-12
CCT007093   PPM1D   483 14-MAY-12
CCT018159   HSP90   471 30-APR-12
CEP-701 CEP-701 FLT3, JAK2, NTRK1, RET 126565 577 14-MAY-12
CGP-082996 CINK4,KIN001-021 CDK4 24825971 359 16-MAR-12
CGP-60474 KIN001-019 CDK1/2/5/7/9 644215 359 16-MAR-12
CHIR-99021 CT 99021 GSK3B 9956119 668 26-MAR-12
CI-1040 PD-18435,PD-184352 MEK1/2 6918454 574 30-APR-12
CMK KIN001-128 RSK   359 16-MAR-12
Camptothecin 7-Ethyl-10-Hydroxy-Camptothecin,SN-38 TOP1 104842 577 14-MAY-12
Cisplatin cis-Diammineplatinum(II) dichloride DNA crosslinker 84691 577 14-MAY-12
Cyclopamine 11-deoxojervine SMO 442972 355 16-MAR-12
Cytarabine Ara-Cytidine,Arabinosyl Cytosine,U-19920 DNA synthesis 6253 577 14-MAY-12
DMOG Dimethyloxalylglcine Prolyl-4-Hydroxylase 560326 668 26-MAR-12
Dasatinib KIN001-005 ABL, SRC, KIT, PDGFR 3062316 359 16-MAR-12
Docetaxel RP-56976 Microtubules 148124 568 14-MAY-12
Doxorubicin Doxil,Rubex DNA intercalating 31703 662 26-MAR-12
EHT 1864   Rac GTPases   483 14-MAY-12
Elesclomol   HSP70   577 14-MAY-12
Embelin   XIAP 3218 662 26-MAR-12
Epothilone B GNF-PF-193 Microtubules 448013 662 26-MAR-12
Erlotinib   EGFR 176870 329 16-MAR-12
Etoposide   TOP2 36462 668 26-MAR-12
FH535 FH535 unknown 3463933 662 26-MAR-12
FTI-277   Farnesyl transferase (FNTA) 3005532 668 26-MAR-12
GDC-0449   SMO 24776445 564 14-MAY-12
GDC0941   PI3K (class 1) 17755052 532 14-MAY-12
GNF-2 KIN001-013 (GNF-2 / 3-(6-(4-(trifluoromethoxy)phenylamino)pyrimidin-4-yl)benzamide) BCR-ABL 5311510 359 16-MAR-12
GSK-650394   SGK3 25022668 662 26-MAR-12
GSK269962A KIN001-155 ROCK 16095342 358 16-MAR-12
GW 441756   NTRK1   577 14-MAY-12
GW843682X KIN001-134 PLK1 15983966 360 16-MAR-12
Gefitinib ZD-1839 EGFR 123631 577 14-MAY-12
Gemcitabine Gemzar, LY-188011 DNA replication 60750 662 26-MAR-12
IPA-3 IPA-3 PAK 521106 662 26-MAR-12
Imatinib Gleevec,STI-571 ABL, KIT, PDGFR 5291 362 16-MAR-12
JNJ-26854165   MDM2 11609586 480 14-MAY-12
JNK Inhibitor VIII JNK Inhibitor VIII JNK 11624601 574 14-MAY-12
JNK-9L KIN001-204 JNK   668 26-MAR-12
JW-7-52-1   MTOR 49836027 360 16-MAR-12
KIN001-135 KIN001-135 IKKE 11626927 359 16-MAR-12
KU-55933   ATM 5278396 552 14-MAY-12
LFM-A13 DDE-28 BTK 9549280 662 26-MAR-12
Lapatinib   EGFR, ERBB2 208908 352 16-MAR-12
Lenalidomide   TNF alpha 216326 577 14-MAY-12
MG-132 zLLL Proteasome 462382 358 16-MAR-12
MK-2206   AKT1/2   531 14-MAY-12
MS-275 MS275 HDAC 4261 355 16-MAR-12
Metformin 1,1-Dimethylbiguanide hydrochloride AMPK agonist 4091 576 14-MAY-12
Methotrexate   Dihydrofolate reductase (DHFR) 126941 545 14-MAY-12
Midostaurin PKC 412 KIT 24202429 668 26-MAR-12
Mitomycin C Mytozytrex,NSC-26980 DNA crosslinker 5746 662 26-MAR-12
NSC-87877   SHP1/2 (PTN6/11) 5459322 668 26-MAR-12
NU-7441 NU-7432,KU-57788 DNAPK 11327430 552 14-MAY-12
NVP-BEZ235 BEZ235 PI3K (Class 1) and mTORC1/2   552 14-MAY-12
NVP-TAE684 KIN001-017 ALK 16038120 362 16-MAR-12
Nilotinib   ABL 644241 577 14-MAY-12
Nutlin-3a Nutlin-3a (-) enantiomer MDM2 11433190 561 14-MAY-12
OSI-906 OSI-906 IFG1R 11640390 662 26-MAR-12
Obatoclax Mesylate   BCL-2, BCL-XL, MCL-1 16727411 662 26-MAR-12
PAC-1 PAC-1 CASP3 activator 6851947 662 26-MAR-12
PD-0325901 PD-0325901 MEK1/2 9826528 554 14-MAY-12
PD-0332991 PD-0332991 CDK4/6 5330286 531 14-MAY-12
PD-173074 PD-173074 FGFR1/3 1401 561 14-MAY-12
PF-02341066 Crizotinib,KIN001-023 MET, ALK 11496366 362 16-MAR-12
PF-4708671   p70 S6KA   480 14-MAY-12
PF-562271 (KIN001-205) FAK 11713159 668 26-MAR-12
PHA-665752   MET 10461815 362 16-MAR-12
PLX4720   BRAF 24180719 572 14-MAY-12
Paclitaxel BMS-181339-01 Microtubules 36314 360 16-MAR-12
Parthenolide   NFKB1 5420805 359 16-MAR-12
Pazopanib GW786034 VEGFR, PDGFRA, PDGFRB, KIT 10113978 662 26-MAR-12
Pyrimethamine   Dihydrofolate reductase (DHFR) 4993 358 16-MAR-12
QS11 QS11 ARFGAP   662 26-MAR-12
RDEA119 RDEA119 MEK1/2 44182295 554 14-MAY-12
RO-3306   CDK1 44450571 561 14-MAY-12
Rapamycin AY-22989,Sirolimus,WY-090217 MTOR 5284616 362 16-MAR-12
Roscovitine Seliciclib CDKs 160355 352 16-MAR-12
S-Trityl-L-cysteine NSC 83265 KIF11 76044 359 16-MAR-12
SB 216763 SB 216763 GSK3A/B   558 30-APR-12
SB590885   BRAF 11316960 541 14-MAY-12
SL 0101-1   RSK, AURKB, PIM3   570 30-APR-12
Salubrinal 3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide GADD34-PP1C phosphatase 5717801 356 16-MAR-12
Shikonin Shikonin unknown 5208 668 26-MAR-12
Sorafenib BAY-43-9006,Nexavar PDGFRA, PDGFRB, KDR, KIT, FLT3 216239 358 16-MAR-12
Sunitinib Sutent PDGFRA, PDGFRB, KDR, KIT, FLT3 5329102 359 16-MAR-12
TW 37   BCL-2, BCL-XL 11455910 480 14-MAY-12
Temsirolimus CCI-779 MTOR 6918289 577 14-MAY-12
Thapsigargin   ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 446378 662 26-MAR-12
Tipifarnib   Farnesyl-transferase (FNTA) 159324 662 26-MAR-12
VX-680 MK-045,MK-0457,VX-68 Aurora A/B/C, FLT3, ABL1, JAK2, 5494449 359 16-MAR-12
VX-702   p38 10341154 574 14-MAY-12
Vinblastine Vinblastine sulphate Microtubules 6710780 577 14-MAY-12
Vinorelbine   Microtubules 60780 668 26-MAR-12
Vorinostat SAHA HDAC inhibitor Class I, IIa, IIb, IV 5311 558 14-MAY-12
WH-4-023 KIN001-112 SRC family, ABL 11844351 359 16-MAR-12
WO2009093972 AZD6482 PI3Kb   469 14-MAY-12
WZ-1-84 KIN001-123 BMX 49821040 359 16-MAR-12
XMD8-85 XMD8-85 ERK5 (MK07) 46844147 355 16-MAR-12
Z-LLNle-CHO Z-L-Norleucine-CHO g-secretase 16760646 359 16-MAR-12
ZM-447439 ZM447439 AURKB 9914412 561 14-MAY-12
Name Synonyms Targets PubCHEM Sample size Last screening date
A-443654 KIN001-139 AKT1/2/3 10172943 359 16-MAR-12
A-770041 A770041,KIN001-111 SRC family 9549184 360 16-MAR-12
ABT-263   BCL2, BCL-XL, BCL-W 24978538 561 14-MAY-12
ABT-888 ABT-888 PARP1/2 11960529 575 14-MAY-12
AG-014699 PF-01367338 PARP1, PARP2 9931953 480 14-MAY-12
AICAR N1-(b-D-Ribofuranosyl)-5-aminoimidazole-4-carboxamide AMPK agonist 65110 563 14-MAY-12
AKT inhibitor VIII   AKT1/2 16218954 668 26-MAR-12
AMG-706 AMG-706 VEGFR, RET, c-KIT, PDGFR 11667893 561 14-MAY-12
AP-24534 AP24534 (KIN001-192) ABL 24826799 668 26-MAR-12
AS601245 AS601245 JNK 11422035 662 26-MAR-12
ATRA Tretinoin Retinoic acid and retinoid X receptor agonist 444795 574 14-MAY-12
AUY922 VER-52296,NVP-AUY922 HSP90 10096043 662 26-MAR-12
AZ628   BRAF 11676786 355 16-MAR-12
AZD-0530 Saracatinib,KIN001-045 SRC, ABL1 10302451 362 16-MAR-12
AZD-2281 KU-0059436, Olaparib PARP1/2 23725625 558 14-MAY-12
AZD6244   MEK1/2 10127622 531 14-MAY-12
AZD6482 AZD6482 (KIN001-193) PI3Kb (P3C2B) 44137675 668 26-MAR-12
AZD7762 AZD 7762 CHK1/2   575 14-MAY-12
AZD8055 AZD8055 mTORC1/2   554 14-MAY-12
Axitinib AG-013736 PDGFR, KIT, VEGFR 6450551 577 14-MAY-12
Name Synonyms Targets PubCHEM Sample size Last screening date
BAY 61-3606   SYK 16760671 662 26-MAR-12
BI-2536 KIN001-124 PLK1/2/3 11364421 360 16-MAR-12
BI-D1870 BI-D1870 RSK1/2/3/5, PLK1, AURKB 25023738 574 14-MAY-12
BIBW2992 Tovok, Afatinib EGFR, ERBB2 10184653 577 14-MAY-12
BIRB 0796   p38, JNK2 156422 574 14-MAY-12
BMS-509744 KIN001-127 ITK 20635522 360 16-MAR-12
BMS-536924 KIN001-126 IGF1R 10390396 360 16-MAR-12
BMS-708163 Avagacestat gamma-secretase 46883536 483 14-MAY-12
BMS-754807   IGF1R 24785538 662 26-MAR-12
BX-795 BX 795 TBK1, PDK1, IKK, AURKB/C 10077147 539 14-MAY-12
Bexarotene LG-100069,LGD-1069 Retinioic acid X family agonist 82146 662 26-MAR-12
Bicalutamide ICI-176334 Androgen receptor (ANDR) 2375 662 26-MAR-12
Bleomycin   DNA damage 5460769 662 26-MAR-12
Bortezomib LDP-341,PS-341 Proteasome 387447 355 16-MAR-12
Bosutinib SKI-606 SRC, ABL, TEC 5328940 575 14-MAY-12
Bryostatin 1 Bryostatin 1 PRKC 5280757 662 26-MAR-12
Name Synonyms Targets PubCHEM Sample size Last screening date
CCT007093   PPM1D   483 14-MAY-12
CCT018159   HSP90   471 30-APR-12
CEP-701 CEP-701 FLT3, JAK2, NTRK1, RET 126565 577 14-MAY-12
CGP-082996 CINK4,KIN001-021 CDK4 24825971 359 16-MAR-12
CGP-60474 KIN001-019 CDK1/2/5/7/9 644215 359 16-MAR-12
CHIR-99021 CT 99021 GSK3B 9956119 668 26-MAR-12
CI-1040 PD-18435,PD-184352 MEK1/2 6918454 574 30-APR-12
CMK KIN001-128 RSK   359 16-MAR-12
Camptothecin 7-Ethyl-10-Hydroxy-Camptothecin,SN-38 TOP1 104842 577 14-MAY-12
Cisplatin cis-Diammineplatinum(II) dichloride DNA crosslinker 84691 577 14-MAY-12
Cyclopamine 11-deoxojervine SMO 442972 355 16-MAR-12
Cytarabine Ara-Cytidine,Arabinosyl Cytosine,U-19920 DNA synthesis 6253 577 14-MAY-12
Name Synonyms Targets PubCHEM Sample size Last screening date
DMOG Dimethyloxalylglcine Prolyl-4-Hydroxylase 560326 668 26-MAR-12
Dasatinib KIN001-005 ABL, SRC, KIT, PDGFR 3062316 359 16-MAR-12
Docetaxel RP-56976 Microtubules 148124 568 14-MAY-12
Doxorubicin Doxil,Rubex DNA intercalating 31703 662 26-MAR-12
Name Synonyms Targets PubCHEM Sample size Last screening date
EHT 1864   Rac GTPases   483 14-MAY-12
Elesclomol   HSP70   577 14-MAY-12
Embelin   XIAP 3218 662 26-MAR-12
Epothilone B GNF-PF-193 Microtubules 448013 662 26-MAR-12
Erlotinib   EGFR 176870 329 16-MAR-12
Etoposide   TOP2 36462 668 26-MAR-12
Name Synonyms Targets PubCHEM Sample size Last screening date
FH535 FH535 unknown 3463933 662 26-MAR-12
FTI-277   Farnesyl transferase (FNTA) 3005532 668 26-MAR-12
Name Synonyms Targets PubCHEM Sample size Last screening date
GDC-0449   SMO 24776445 564 14-MAY-12
GDC0941   PI3K (class 1) 17755052 532 14-MAY-12
GNF-2 KIN001-013 (GNF-2 / 3-(6-(4-(trifluoromethoxy)phenylamino)pyrimidin-4-yl)benzamide) BCR-ABL 5311510 359 16-MAR-12
GSK-650394   SGK3 25022668 662 26-MAR-12
GSK269962A KIN001-155 ROCK 16095342 358 16-MAR-12
GW 441756   NTRK1   577 14-MAY-12
GW843682X KIN001-134 PLK1 15983966 360 16-MAR-12
Gefitinib ZD-1839 EGFR 123631 577 14-MAY-12
Gemcitabine Gemzar, LY-188011 DNA replication 60750 662 26-MAR-12

No drugs in list

Name Synonyms Targets PubCHEM Sample size Last screening date
IPA-3 IPA-3 PAK 521106 662 26-MAR-12
Imatinib Gleevec,STI-571 ABL, KIT, PDGFR 5291 362 16-MAR-12
Name Synonyms Targets PubCHEM Sample size Last screening date
JNJ-26854165   MDM2 11609586 480 14-MAY-12
JNK Inhibitor VIII JNK Inhibitor VIII JNK 11624601 574 14-MAY-12
JNK-9L KIN001-204 JNK   668 26-MAR-12
JW-7-52-1   MTOR 49836027 360 16-MAR-12
Name Synonyms Targets PubCHEM Sample size Last screening date
KIN001-135 KIN001-135 IKKE 11626927 359 16-MAR-12
KU-55933   ATM 5278396 552 14-MAY-12
Name Synonyms Targets PubCHEM Sample size Last screening date
LFM-A13 DDE-28 BTK 9549280 662 26-MAR-12
Lapatinib   EGFR, ERBB2 208908 352 16-MAR-12
Lenalidomide   TNF alpha 216326 577 14-MAY-12
Name Synonyms Targets PubCHEM Sample size Last screening date
MG-132 zLLL Proteasome 462382 358 16-MAR-12
MK-2206   AKT1/2   531 14-MAY-12
MS-275 MS275 HDAC 4261 355 16-MAR-12
Metformin 1,1-Dimethylbiguanide hydrochloride AMPK agonist 4091 576 14-MAY-12
Methotrexate   Dihydrofolate reductase (DHFR) 126941 545 14-MAY-12
Midostaurin PKC 412 KIT 24202429 668 26-MAR-12
Mitomycin C Mytozytrex,NSC-26980 DNA crosslinker 5746 662 26-MAR-12
Name Synonyms Targets PubCHEM Sample size Last screening date
NSC-87877   SHP1/2 (PTN6/11) 5459322 668 26-MAR-12
NU-7441 NU-7432,KU-57788 DNAPK 11327430 552 14-MAY-12
NVP-BEZ235 BEZ235 PI3K (Class 1) and mTORC1/2   552 14-MAY-12
NVP-TAE684 KIN001-017 ALK 16038120 362 16-MAR-12
Nilotinib   ABL 644241 577 14-MAY-12
Nutlin-3a Nutlin-3a (-) enantiomer MDM2 11433190 561 14-MAY-12
Name Synonyms Targets PubCHEM Sample size Last screening date
OSI-906 OSI-906 IFG1R 11640390 662 26-MAR-12
Obatoclax Mesylate   BCL-2, BCL-XL, MCL-1 16727411 662 26-MAR-12
Name Synonyms Targets PubCHEM Sample size Last screening date
PAC-1 PAC-1 CASP3 activator 6851947 662 26-MAR-12
PD-0325901 PD-0325901 MEK1/2 9826528 554 14-MAY-12
PD-0332991 PD-0332991 CDK4/6 5330286 531 14-MAY-12
PD-173074 PD-173074 FGFR1/3 1401 561 14-MAY-12
PF-02341066 Crizotinib,KIN001-023 MET, ALK 11496366 362 16-MAR-12
PF-4708671   p70 S6KA   480 14-MAY-12
PF-562271 (KIN001-205) FAK 11713159 668 26-MAR-12
PHA-665752   MET 10461815 362 16-MAR-12
PLX4720   BRAF 24180719 572 14-MAY-12
Paclitaxel BMS-181339-01 Microtubules 36314 360 16-MAR-12
Parthenolide   NFKB1 5420805 359 16-MAR-12
Pazopanib GW786034 VEGFR, PDGFRA, PDGFRB, KIT 10113978 662 26-MAR-12
Pyrimethamine   Dihydrofolate reductase (DHFR) 4993 358 16-MAR-12
Name Synonyms Targets PubCHEM Sample size Last screening date
QS11 QS11 ARFGAP   662 26-MAR-12
Name Synonyms Targets PubCHEM Sample size Last screening date
RDEA119 RDEA119 MEK1/2 44182295 554 14-MAY-12
RO-3306   CDK1 44450571 561 14-MAY-12
Rapamycin AY-22989,Sirolimus,WY-090217 MTOR 5284616 362 16-MAR-12
Roscovitine Seliciclib CDKs 160355 352 16-MAR-12
Name Synonyms Targets PubCHEM Sample size Last screening date
S-Trityl-L-cysteine NSC 83265 KIF11 76044 359 16-MAR-12
SB 216763 SB 216763 GSK3A/B   558 30-APR-12
SB590885   BRAF 11316960 541 14-MAY-12
SL 0101-1   RSK, AURKB, PIM3   570 30-APR-12
Salubrinal 3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide GADD34-PP1C phosphatase 5717801 356 16-MAR-12
Shikonin Shikonin unknown 5208 668 26-MAR-12
Sorafenib BAY-43-9006,Nexavar PDGFRA, PDGFRB, KDR, KIT, FLT3 216239 358 16-MAR-12
Sunitinib Sutent PDGFRA, PDGFRB, KDR, KIT, FLT3 5329102 359 16-MAR-12
Name Synonyms Targets PubCHEM Sample size Last screening date
TW 37   BCL-2, BCL-XL 11455910 480 14-MAY-12
Temsirolimus CCI-779 MTOR 6918289 577 14-MAY-12
Thapsigargin   ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 446378 662 26-MAR-12
Tipifarnib   Farnesyl-transferase (FNTA) 159324 662 26-MAR-12

No drugs in list

Name Synonyms Targets PubCHEM Sample size Last screening date
VX-680 MK-045,MK-0457,VX-68 Aurora A/B/C, FLT3, ABL1, JAK2, 5494449 359 16-MAR-12
VX-702   p38 10341154 574 14-MAY-12
Vinblastine Vinblastine sulphate Microtubules 6710780 577 14-MAY-12
Vinorelbine   Microtubules 60780 668 26-MAR-12
Vorinostat SAHA HDAC inhibitor Class I, IIa, IIb, IV 5311 558 14-MAY-12
Name Synonyms Targets PubCHEM Sample size Last screening date
WH-4-023 KIN001-112 SRC family, ABL 11844351 359 16-MAR-12
WO2009093972 AZD6482 PI3Kb   469 14-MAY-12
WZ-1-84 KIN001-123 BMX 49821040 359 16-MAR-12
Name Synonyms Targets PubCHEM Sample size Last screening date
XMD8-85 XMD8-85 ERK5 (MK07) 46844147 355 16-MAR-12

No drugs in list

Name Synonyms Targets PubCHEM Sample size Last screening date
Z-LLNle-CHO Z-L-Norleucine-CHO g-secretase 16760646 359 16-MAR-12
ZM-447439 ZM447439 AURKB 9914412 561 14-MAY-12
Name Synonyms Targets PubCHEM Sample size Last screening date
17-AAG 17-AAG HSP90 6505803 574 14-MAY-12
681640 681640 WEE1, CHK1 10384072 541 14-MAY-12

Legacy genes

These web pages contain an older drug sensitivity dataset that is separate from our main screening dataset. These data were generated using a different screening format (McDermott et al, PNAS December 11, 2007 vol. 104 no. 50 19936-19941) and are maintained as a resource but are not updated with new data or analyses. In many instances new datasets have been generated for these compounds and are available.

Name Conc Range(uM) Putative Target(s) Source Sample Size Last Updated
Erlotinib 0-2 EGFR Academic collaboration 352 14/03/10
Rapamycin 0-10 MTOR Calbiochem 352 14/03/10
Sunitinib 0-10 PDGFRA,  KIT,  FLT3 Pfizer 352 14/03/10
PHA665752 0-1 MET Pfizer 352 14/03/10
MG-132 0-1 [26S proteasome] Calbiochem 352 14/03/10
Paclitaxel 0-0.1 [ß subunit of tubulin] LKT Laboratories 352 14/03/10
HKI-272 0-2 EGFRERBB2 Wyeth 352 14/03/10
Cyclopamine 0-10 SMO LKT Laboratories 352 14/03/10
Gö 6976 0-10 PRKCAPRKCB Calbiochem 352 14/03/10
Geldanamycin 0-1 HSP90AA1HSP90AB1 LKT Laboratories 352 14/03/10
AZ628 0-2 BRAFRAF1 AstraZeneca 352 14/03/10
Sorafenib 0-2 PDGFRAKITKDRFLT3 LC Laboratories 350 14/03/10
MK-0457 0-2 AURKAAURKBAURKCABL1 Academic collaboration 350 14/03/10
Imatinib 0-2 ABL1KITPDGFRA Academic collaboration 350 14/03/10
TAE684 0-2 ALK Academic collaboration 350 14/03/10
PD173074 0-2 FGFR1FGFR3 Calbiochem 350 14/03/10
PF-2341066 0-2 METALK Academic collaboration 350 14/03/10
AZD0530 0-2 SRC Academic collaboration 350 14/03/10

Contact us | Cookies policy | Terms & Conditions. This site is hosted by the Wellcome Trust Sanger Institute.