Drugs

For this analysis we have correlated drug sensitivity data with genomic datasets to identify molecular features associated with drug sensitivity and resistance.

Name Synonyms Targets PubCHEM Sample size Last screening date
17-AAG 17-AAG HSP90 6505803 661 05-FEB-13
681640 681640 WEE1, CHK1 10384072 641 05-FEB-13
A-443654 KIN001-139 AKT1/2/3 10172943 355 16-MAR-12
A-770041 A770041,KIN001-111 SRC family 9549184 356 16-MAR-12
ABT-263   BCL2, BCL-XL, BCL-W 24978538 661 05-FEB-13
ABT-888 ABT-888 PARP1/2 11960529 663 05-FEB-13
AG-014699 PF-01367338 PARP1, PARP2 9931953 653 05-FEB-13
AICAR N1-(b-D-Ribofuranosyl)-5-aminoimidazole-4-carboxamide AMPK agonist 65110 663 05-FEB-13
AKT inhibitor VIII   AKT1/2 16218954 672 14-MAY-12
AMG-706 AMG-706 VEGFR, RET, c-KIT, PDGFR 11667893 661 05-FEB-13
AP-24534 AP24534 (KIN001-192) ABL 24826799 672 14-MAY-12
AS601245 AS601245 JNK 11422035 665 14-MAY-12
ATRA Tretinoin Retinoic acid and retinoid X receptor agonist 444795 663 05-FEB-13
AUY922 VER-52296,NVP-AUY922 HSP90 10096043 665 14-MAY-12
AZ628   BRAF 11676786 351 16-MAR-12
AZD-0530 Saracatinib,KIN001-045 SRC, ABL1 10302451 359 16-MAR-12
AZD-2281 KU-0059436, Olaparib PARP1/2 23725625 663 05-FEB-13
AZD6244   MEK1/2 10127622 633 05-FEB-13
AZD6482 AZD6482 (KIN001-193) PI3Kb (P3C2B) 44137675 672 14-MAY-12
AZD6482 WO2009093972 PI3Kb   641 05-FEB-13
AZD7762 AZD 7762 CHK1/2   663 05-FEB-13
AZD8055 AZD8055 mTORC1/2   654 05-FEB-13
Axitinib AG-013736 PDGFR, KIT, VEGFR 6450551 663 05-FEB-13
BAY 61-3606   SYK 16760671 665 14-MAY-12
BI-2536 KIN001-124 PLK1/2/3 11364421 356 16-MAR-12
BIBW2992 Tovok, Afatinib EGFR, ERBB2 10184653 663 05-FEB-13
BIRB 0796   p38, JNK2 156422 661 05-FEB-13
BMS-509744 KIN001-127 ITK 20635522 356 16-MAR-12
BMS-536924 KIN001-126 IGF1R 10390396 356 16-MAR-12
BMS-708163 Avagacestat gamma-secretase 46883536 655 05-FEB-13
BMS-754807   IGF1R 24785538 665 14-MAY-12
BX-795 BX 795 TBK1, PDK1, IKK, AURKB/C 10077147 659 05-FEB-13
Bexarotene LG-100069,LGD-1069 Retinioic acid X family agonist 82146 665 14-MAY-12
Bicalutamide ICI-176334 Androgen receptor (ANDR) 2375 665 14-MAY-12
Bleomycin   DNA damage 5460769 665 14-MAY-12
Bortezomib LDP-341,PS-341 Proteasome 387447 350 16-MAR-12
Bosutinib SKI-606 SRC, ABL, TEC 5328940 663 05-FEB-13
Bryostatin 1 Bryostatin 1 PRKC 5280757 665 14-MAY-12
CCT007093   PPM1D   655 05-FEB-13
CCT018159   HSP90   644 05-FEB-13
CEP-701 CEP-701 FLT3, JAK2, NTRK1, RET 126565 663 05-FEB-13
CGP-082996 CINK4,KIN001-021 CDK4 24825971 355 16-MAR-12
CGP-60474 KIN001-019 CDK1/2/5/7/9 644215 355 16-MAR-12
CHIR-99021 CT 99021 GSK3B 9956119 672 14-MAY-12
CI-1040 PD-18435,PD-184352 MEK1/2 6918454 659 05-FEB-13
CMK KIN001-128 RSK   355 16-MAR-12
Camptothecin 7-Ethyl-10-Hydroxy-Camptothecin,SN-38 TOP1 104842 663 05-FEB-13
Cisplatin cis-Diammineplatinum(II) dichloride DNA crosslinker 84691 663 05-FEB-13
Cyclopamine 11-deoxojervine SMO 442972 350 16-MAR-12
Cytarabine Ara-Cytidine,Arabinosyl Cytosine,U-19920 DNA synthesis 6253 663 05-FEB-13
DMOG Dimethyloxalylglcine Prolyl-4-Hydroxylase 560326 672 14-MAY-12
Dasatinib KIN001-005 ABL, SRC, KIT, PDGFR 3062316 355 16-MAR-12
Docetaxel RP-56976 Microtubules 148124 663 05-FEB-13
Doxorubicin Doxil,Rubex DNA intercalating 31703 665 14-MAY-12
EHT 1864   Rac GTPases   655 05-FEB-13
Elesclomol   HSP70   663 05-FEB-13
Embelin   XIAP 3218 665 14-MAY-12
Epothilone B GNF-PF-193 Microtubules 448013 665 14-MAY-12
Erlotinib   EGFR 176870 323 16-MAR-12
Etoposide   TOP2 36462 672 14-MAY-12
FH535 FH535 unknown 3463933 665 14-MAY-12
FTI-277   Farnesyl transferase (FNTA) 3005532 672 14-MAY-12
GDC-0449   SMO 24776445 663 05-FEB-13
GDC0941   PI3K (class 1) 17755052 652 05-FEB-13
GNF-2 KIN001-013 (GNF-2 / 3-(6-(4-(trifluoromethoxy)phenylamino)pyrimidin-4-yl)benzamide) BCR-ABL 5311510 355 16-MAR-12
GSK-1904529A GSK1904529A IGF1R 25124816 665 14-MAY-12
GSK-650394   SGK3 25022668 665 14-MAY-12
GSK269962A KIN001-155 ROCK 16095342 353 16-MAR-12
GW 441756   NTRK1   663 05-FEB-13
GW843682X KIN001-134 PLK1 15983966 356 16-MAR-12
Gefitinib ZD-1839 EGFR 123631 663 05-FEB-13
Gemcitabine Gemzar, LY-188011 DNA replication 60750 665 14-MAY-12
IPA-3 IPA-3 PAK 521106 665 14-MAY-12
Imatinib Gleevec,STI-571 ABL, KIT, PDGFR 5291 359 16-MAR-12
JNJ-26854165   MDM2 11609586 653 05-FEB-13
JNK Inhibitor VIII JNK Inhibitor VIII JNK 11624601 661 05-FEB-13
JNK-9L KIN001-204 JNK   672 14-MAY-12
JW-7-52-1   MTOR 49836027 356 16-MAR-12
KIN001-135 KIN001-135 IKKE 11626927 353 16-MAR-12
KU-55933   ATM 5278396 659 05-FEB-13
LAQ824 Dacinostat, NVP-LAQ824 HDAC 6445533 665 14-MAY-12
LFM-A13 DDE-28 BTK 9549280 665 14-MAY-12
Lapatinib   EGFR, ERBB2 208908 348 16-MAR-12
Lenalidomide   TNF alpha 216326 663 05-FEB-13
MG-132 zLLL Proteasome 462382 352 16-MAR-12
MK-2206   AKT1/2   633 05-FEB-13
MS-275 MS275 HDAC 4261 351 16-MAR-12
Methotrexate   Dihydrofolate reductase (DHFR) 126941 663 05-FEB-13
Midostaurin PKC 412 KIT 24202429 672 14-MAY-12
Mitomycin C Mytozytrex,NSC-26980 DNA crosslinker 5746 665 14-MAY-12
NSC-87877   SHP1/2 (PTN6/11) 5459322 672 14-MAY-12
NU-7441 NU-7432,KU-57788 DNAPK 11327430 659 05-FEB-13
NVP-BEZ235 BEZ235 PI3K (Class 1) and mTORC1/2   654 05-FEB-13
NVP-TAE684 KIN001-017 ALK 16038120 357 16-MAR-12
Nilotinib   ABL 644241 645 05-FEB-13
Nutlin-3a Nutlin-3a (-) enantiomer MDM2 11433190 661 05-FEB-13
OSI-906 OSI-906 IGF1R 11640390 665 14-MAY-12
OSU-03012 AR-12 PDK1 (PDPK1) 10027278 665 14-MAY-12
Obatoclax Mesylate   BCL-2, BCL-XL, MCL-1 16727411 665 14-MAY-12
PAC-1 PAC-1 CASP3 activator 6851947 665 14-MAY-12
PD-0325901 PD-0325901 MEK1/2 9826528 654 05-FEB-13
PD-0332991 PD-0332991 CDK4/6 5330286 633 05-FEB-13
PD-173074 PD-173074 FGFR1/3 1401 661 05-FEB-13
PF-02341066 Crizotinib,KIN001-023 MET, ALK 11496366 357 16-MAR-12
PF-4708671   p70 S6KA   653 05-FEB-13
PF-562271 (KIN001-205) FAK 11713159 672 14-MAY-12
PHA-665752   MET 10461815 358 16-MAR-12
PLX4720   BRAF 24180719 661 05-FEB-13
Paclitaxel BMS-181339-01 Microtubules 36314 356 16-MAR-12
Parthenolide   NFKB1 5420805 353 16-MAR-12
Pazopanib GW786034 VEGFR, PDGFRA, PDGFRB, KIT 10113978 665 14-MAY-12
Pyrimethamine   Dihydrofolate reductase (DHFR) 4993 353 16-MAR-12
QS11 QS11 ARFGAP   665 14-MAY-12
RDEA119 RDEA119 MEK1/2 44182295 654 05-FEB-13
RO-3306   CDK1 44450571 661 05-FEB-13
Rapamycin AY-22989,Sirolimus,WY-090217 MTOR 5284616 357 16-MAR-12
Roscovitine Seliciclib CDKs 160355 348 16-MAR-12
S-Trityl-L-cysteine NSC 83265 KIF11 76044 355 16-MAR-12
SB 216763 SB 216763 GSK3A/B   632 05-FEB-13
SB590885   BRAF 11316960 641 05-FEB-13
SL 0101-1   RSK, AURKB, PIM3   657 05-FEB-13
Salubrinal 3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide GADD34-PP1C phosphatase 5717801 351 16-MAR-12
Shikonin Shikonin unknown 5208 672 14-MAY-12
Sorafenib BAY-43-9006,Nexavar PDGFRA, PDGFRB, KDR, KIT, FLT3 216239 354 16-MAR-12
Sunitinib Sutent PDGFRA, PDGFRB, KDR, KIT, FLT3 5329102 355 16-MAR-12
TGX221   PI3K beta 9907093 352 16-MAR-12
TW 37   BCL-2, BCL-XL 11455910 653 05-FEB-13
Temsirolimus CCI-779 MTOR 6918289 663 05-FEB-13
Thapsigargin   ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 446378 665 14-MAY-12
Tipifarnib   Farnesyl-transferase (FNTA) 159324 665 14-MAY-12
VX-680 MK-045,MK-0457,VX-68 Aurora A/B/C, FLT3, ABL1, JAK2, 5494449 355 16-MAR-12
VX-702   p38 10341154 663 05-FEB-13
Vinblastine Vinblastine sulphate Microtubules 6710780 663 05-FEB-13
Vinorelbine   Microtubules 60780 672 14-MAY-12
Vorinostat SAHA HDAC inhibitor Class I, IIa, IIb, IV 5311 663 05-FEB-13
WH-4-023 KIN001-112 SRC family, ABL 11844351 355 16-MAR-12
WZ-1-84 KIN001-123 BMX 49821040 355 16-MAR-12
XMD8-85 XMD8-85 ERK5 (MK07) 46844147 350 16-MAR-12
Z-LLNle-CHO Z-L-Norleucine-CHO g-secretase 16760646 355 16-MAR-12
ZM-447439 ZM447439 AURKB 9914412 642 05-FEB-13
Name Synonyms Targets PubCHEM Sample size Last screening date
A-443654 KIN001-139 AKT1/2/3 10172943 355 16-MAR-12
A-770041 A770041,KIN001-111 SRC family 9549184 356 16-MAR-12
ABT-263   BCL2, BCL-XL, BCL-W 24978538 661 05-FEB-13
ABT-888 ABT-888 PARP1/2 11960529 663 05-FEB-13
AG-014699 PF-01367338 PARP1, PARP2 9931953 653 05-FEB-13
AICAR N1-(b-D-Ribofuranosyl)-5-aminoimidazole-4-carboxamide AMPK agonist 65110 663 05-FEB-13
AKT inhibitor VIII   AKT1/2 16218954 672 14-MAY-12
AMG-706 AMG-706 VEGFR, RET, c-KIT, PDGFR 11667893 661 05-FEB-13
AP-24534 AP24534 (KIN001-192) ABL 24826799 672 14-MAY-12
AS601245 AS601245 JNK 11422035 665 14-MAY-12
ATRA Tretinoin Retinoic acid and retinoid X receptor agonist 444795 663 05-FEB-13
AUY922 VER-52296,NVP-AUY922 HSP90 10096043 665 14-MAY-12
AZ628   BRAF 11676786 351 16-MAR-12
AZD-0530 Saracatinib,KIN001-045 SRC, ABL1 10302451 359 16-MAR-12
AZD-2281 KU-0059436, Olaparib PARP1/2 23725625 663 05-FEB-13
AZD6244   MEK1/2 10127622 633 05-FEB-13
AZD6482 AZD6482 (KIN001-193) PI3Kb (P3C2B) 44137675 672 14-MAY-12
AZD6482 WO2009093972 PI3Kb   641 05-FEB-13
AZD7762 AZD 7762 CHK1/2   663 05-FEB-13
AZD8055 AZD8055 mTORC1/2   654 05-FEB-13
Axitinib AG-013736 PDGFR, KIT, VEGFR 6450551 663 05-FEB-13
Name Synonyms Targets PubCHEM Sample size Last screening date
BAY 61-3606   SYK 16760671 665 14-MAY-12
BI-2536 KIN001-124 PLK1/2/3 11364421 356 16-MAR-12
BIBW2992 Tovok, Afatinib EGFR, ERBB2 10184653 663 05-FEB-13
BIRB 0796   p38, JNK2 156422 661 05-FEB-13
BMS-509744 KIN001-127 ITK 20635522 356 16-MAR-12
BMS-536924 KIN001-126 IGF1R 10390396 356 16-MAR-12
BMS-708163 Avagacestat gamma-secretase 46883536 655 05-FEB-13
BMS-754807   IGF1R 24785538 665 14-MAY-12
BX-795 BX 795 TBK1, PDK1, IKK, AURKB/C 10077147 659 05-FEB-13
Bexarotene LG-100069,LGD-1069 Retinioic acid X family agonist 82146 665 14-MAY-12
Bicalutamide ICI-176334 Androgen receptor (ANDR) 2375 665 14-MAY-12
Bleomycin   DNA damage 5460769 665 14-MAY-12
Bortezomib LDP-341,PS-341 Proteasome 387447 350 16-MAR-12
Bosutinib SKI-606 SRC, ABL, TEC 5328940 663 05-FEB-13
Bryostatin 1 Bryostatin 1 PRKC 5280757 665 14-MAY-12
Name Synonyms Targets PubCHEM Sample size Last screening date
CCT007093   PPM1D   655 05-FEB-13
CCT018159   HSP90   644 05-FEB-13
CEP-701 CEP-701 FLT3, JAK2, NTRK1, RET 126565 663 05-FEB-13
CGP-082996 CINK4,KIN001-021 CDK4 24825971 355 16-MAR-12
CGP-60474 KIN001-019 CDK1/2/5/7/9 644215 355 16-MAR-12
CHIR-99021 CT 99021 GSK3B 9956119 672 14-MAY-12
CI-1040 PD-18435,PD-184352 MEK1/2 6918454 659 05-FEB-13
CMK KIN001-128 RSK   355 16-MAR-12
Camptothecin 7-Ethyl-10-Hydroxy-Camptothecin,SN-38 TOP1 104842 663 05-FEB-13
Cisplatin cis-Diammineplatinum(II) dichloride DNA crosslinker 84691 663 05-FEB-13
Cyclopamine 11-deoxojervine SMO 442972 350 16-MAR-12
Cytarabine Ara-Cytidine,Arabinosyl Cytosine,U-19920 DNA synthesis 6253 663 05-FEB-13
Name Synonyms Targets PubCHEM Sample size Last screening date
DMOG Dimethyloxalylglcine Prolyl-4-Hydroxylase 560326 672 14-MAY-12
Dasatinib KIN001-005 ABL, SRC, KIT, PDGFR 3062316 355 16-MAR-12
Docetaxel RP-56976 Microtubules 148124 663 05-FEB-13
Doxorubicin Doxil,Rubex DNA intercalating 31703 665 14-MAY-12
Name Synonyms Targets PubCHEM Sample size Last screening date
EHT 1864   Rac GTPases   655 05-FEB-13
Elesclomol   HSP70   663 05-FEB-13
Embelin   XIAP 3218 665 14-MAY-12
Epothilone B GNF-PF-193 Microtubules 448013 665 14-MAY-12
Erlotinib   EGFR 176870 323 16-MAR-12
Etoposide   TOP2 36462 672 14-MAY-12
Name Synonyms Targets PubCHEM Sample size Last screening date
FH535 FH535 unknown 3463933 665 14-MAY-12
FTI-277   Farnesyl transferase (FNTA) 3005532 672 14-MAY-12
Name Synonyms Targets PubCHEM Sample size Last screening date
GDC-0449   SMO 24776445 663 05-FEB-13
GDC0941   PI3K (class 1) 17755052 652 05-FEB-13
GNF-2 KIN001-013 (GNF-2 / 3-(6-(4-(trifluoromethoxy)phenylamino)pyrimidin-4-yl)benzamide) BCR-ABL 5311510 355 16-MAR-12
GSK-1904529A GSK1904529A IGF1R 25124816 665 14-MAY-12
GSK-650394   SGK3 25022668 665 14-MAY-12
GSK269962A KIN001-155 ROCK 16095342 353 16-MAR-12
GW 441756   NTRK1   663 05-FEB-13
GW843682X KIN001-134 PLK1 15983966 356 16-MAR-12
Gefitinib ZD-1839 EGFR 123631 663 05-FEB-13
Gemcitabine Gemzar, LY-188011 DNA replication 60750 665 14-MAY-12

No drugs in list

Name Synonyms Targets PubCHEM Sample size Last screening date
IPA-3 IPA-3 PAK 521106 665 14-MAY-12
Imatinib Gleevec,STI-571 ABL, KIT, PDGFR 5291 359 16-MAR-12
Name Synonyms Targets PubCHEM Sample size Last screening date
JNJ-26854165   MDM2 11609586 653 05-FEB-13
JNK Inhibitor VIII JNK Inhibitor VIII JNK 11624601 661 05-FEB-13
JNK-9L KIN001-204 JNK   672 14-MAY-12
JW-7-52-1   MTOR 49836027 356 16-MAR-12
Name Synonyms Targets PubCHEM Sample size Last screening date
KIN001-135 KIN001-135 IKKE 11626927 353 16-MAR-12
KU-55933   ATM 5278396 659 05-FEB-13
Name Synonyms Targets PubCHEM Sample size Last screening date
LAQ824 Dacinostat, NVP-LAQ824 HDAC 6445533 665 14-MAY-12
LFM-A13 DDE-28 BTK 9549280 665 14-MAY-12
Lapatinib   EGFR, ERBB2 208908 348 16-MAR-12
Lenalidomide   TNF alpha 216326 663 05-FEB-13
Name Synonyms Targets PubCHEM Sample size Last screening date
MG-132 zLLL Proteasome 462382 352 16-MAR-12
MK-2206   AKT1/2   633 05-FEB-13
MS-275 MS275 HDAC 4261 351 16-MAR-12
Methotrexate   Dihydrofolate reductase (DHFR) 126941 663 05-FEB-13
Midostaurin PKC 412 KIT 24202429 672 14-MAY-12
Mitomycin C Mytozytrex,NSC-26980 DNA crosslinker 5746 665 14-MAY-12
Name Synonyms Targets PubCHEM Sample size Last screening date
NSC-87877   SHP1/2 (PTN6/11) 5459322 672 14-MAY-12
NU-7441 NU-7432,KU-57788 DNAPK 11327430 659 05-FEB-13
NVP-BEZ235 BEZ235 PI3K (Class 1) and mTORC1/2   654 05-FEB-13
NVP-TAE684 KIN001-017 ALK 16038120 357 16-MAR-12
Nilotinib   ABL 644241 645 05-FEB-13
Nutlin-3a Nutlin-3a (-) enantiomer MDM2 11433190 661 05-FEB-13
Name Synonyms Targets PubCHEM Sample size Last screening date
OSI-906 OSI-906 IGF1R 11640390 665 14-MAY-12
OSU-03012 AR-12 PDK1 (PDPK1) 10027278 665 14-MAY-12
Obatoclax Mesylate   BCL-2, BCL-XL, MCL-1 16727411 665 14-MAY-12
Name Synonyms Targets PubCHEM Sample size Last screening date
PAC-1 PAC-1 CASP3 activator 6851947 665 14-MAY-12
PD-0325901 PD-0325901 MEK1/2 9826528 654 05-FEB-13
PD-0332991 PD-0332991 CDK4/6 5330286 633 05-FEB-13
PD-173074 PD-173074 FGFR1/3 1401 661 05-FEB-13
PF-02341066 Crizotinib,KIN001-023 MET, ALK 11496366 357 16-MAR-12
PF-4708671   p70 S6KA   653 05-FEB-13
PF-562271 (KIN001-205) FAK 11713159 672 14-MAY-12
PHA-665752   MET 10461815 358 16-MAR-12
PLX4720   BRAF 24180719 661 05-FEB-13
Paclitaxel BMS-181339-01 Microtubules 36314 356 16-MAR-12
Parthenolide   NFKB1 5420805 353 16-MAR-12
Pazopanib GW786034 VEGFR, PDGFRA, PDGFRB, KIT 10113978 665 14-MAY-12
Pyrimethamine   Dihydrofolate reductase (DHFR) 4993 353 16-MAR-12
Name Synonyms Targets PubCHEM Sample size Last screening date
QS11 QS11 ARFGAP   665 14-MAY-12
Name Synonyms Targets PubCHEM Sample size Last screening date
RDEA119 RDEA119 MEK1/2 44182295 654 05-FEB-13
RO-3306   CDK1 44450571 661 05-FEB-13
Rapamycin AY-22989,Sirolimus,WY-090217 MTOR 5284616 357 16-MAR-12
Roscovitine Seliciclib CDKs 160355 348 16-MAR-12
Name Synonyms Targets PubCHEM Sample size Last screening date
S-Trityl-L-cysteine NSC 83265 KIF11 76044 355 16-MAR-12
SB 216763 SB 216763 GSK3A/B   632 05-FEB-13
SB590885   BRAF 11316960 641 05-FEB-13
SL 0101-1   RSK, AURKB, PIM3   657 05-FEB-13
Salubrinal 3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide GADD34-PP1C phosphatase 5717801 351 16-MAR-12
Shikonin Shikonin unknown 5208 672 14-MAY-12
Sorafenib BAY-43-9006,Nexavar PDGFRA, PDGFRB, KDR, KIT, FLT3 216239 354 16-MAR-12
Sunitinib Sutent PDGFRA, PDGFRB, KDR, KIT, FLT3 5329102 355 16-MAR-12
Name Synonyms Targets PubCHEM Sample size Last screening date
TGX221   PI3K beta 9907093 352 16-MAR-12
TW 37   BCL-2, BCL-XL 11455910 653 05-FEB-13
Temsirolimus CCI-779 MTOR 6918289 663 05-FEB-13
Thapsigargin   ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 446378 665 14-MAY-12
Tipifarnib   Farnesyl-transferase (FNTA) 159324 665 14-MAY-12

No drugs in list

Name Synonyms Targets PubCHEM Sample size Last screening date
VX-680 MK-045,MK-0457,VX-68 Aurora A/B/C, FLT3, ABL1, JAK2, 5494449 355 16-MAR-12
VX-702   p38 10341154 663 05-FEB-13
Vinblastine Vinblastine sulphate Microtubules 6710780 663 05-FEB-13
Vinorelbine   Microtubules 60780 672 14-MAY-12
Vorinostat SAHA HDAC inhibitor Class I, IIa, IIb, IV 5311 663 05-FEB-13
Name Synonyms Targets PubCHEM Sample size Last screening date
WH-4-023 KIN001-112 SRC family, ABL 11844351 355 16-MAR-12
WZ-1-84 KIN001-123 BMX 49821040 355 16-MAR-12
Name Synonyms Targets PubCHEM Sample size Last screening date
XMD8-85 XMD8-85 ERK5 (MK07) 46844147 350 16-MAR-12

No drugs in list

Name Synonyms Targets PubCHEM Sample size Last screening date
Z-LLNle-CHO Z-L-Norleucine-CHO g-secretase 16760646 355 16-MAR-12
ZM-447439 ZM447439 AURKB 9914412 642 05-FEB-13
Name Synonyms Targets PubCHEM Sample size Last screening date
17-AAG 17-AAG HSP90 6505803 661 05-FEB-13
681640 681640 WEE1, CHK1 10384072 641 05-FEB-13

Legacy genes

These web pages contain an older drug sensitivity dataset that is separate from our main screening dataset. These data were generated using a different screening format (McDermott et al, PNAS December 11, 2007 vol. 104 no. 50 19936-19941) and are maintained as a resource but are not updated with new data or analyses. In many instances new datasets have been generated for these compounds and are available.

Name Conc Range(uM) Putative Target(s) Source Sample Size Last Updated
Erlotinib 0-2 EGFR Academic collaboration 352 14/03/10
Rapamycin 0-10 MTOR Calbiochem 352 14/03/10
Sunitinib 0-10 PDGFRA,  KIT,  FLT3 Pfizer 352 14/03/10
PHA665752 0-1 MET Pfizer 352 14/03/10
MG-132 0-1 [26S proteasome] Calbiochem 352 14/03/10
Paclitaxel 0-0.1 [ß subunit of tubulin] LKT Laboratories 352 14/03/10
HKI-272 0-2 EGFRERBB2 Wyeth 352 14/03/10
Cyclopamine 0-10 SMO LKT Laboratories 352 14/03/10
Gö 6976 0-10 PRKCAPRKCB Calbiochem 352 14/03/10
Geldanamycin 0-1 HSP90AA1HSP90AB1 LKT Laboratories 352 14/03/10
AZ628 0-2 BRAFRAF1 AstraZeneca 352 14/03/10
Sorafenib 0-2 PDGFRAKITKDRFLT3 LC Laboratories 350 14/03/10
MK-0457 0-2 AURKAAURKBAURKCABL1 Academic collaboration 350 14/03/10
Imatinib 0-2 ABL1KITPDGFRA Academic collaboration 350 14/03/10
TAE684 0-2 ALK Academic collaboration 350 14/03/10
PD173074 0-2 FGFR1FGFR3 Calbiochem 350 14/03/10
PF-2341066 0-2 METALK Academic collaboration 350 14/03/10
AZD0530 0-2 SRC Academic collaboration 350 14/03/10

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