ANOVA BLCA result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-04-08 10:28:15 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: BLCA specific


Individual Feature analysis: TP53_mut


Feature details and cell panel numbers

Binary feature equal to 1 for samples harboring mutations in TP53

Number of cell lines positive for this feature: 15


Statistically significant associations identified = 3

association id

FEATURE

Drug id

Propr

Public

Drug Name

Drug Target

N FEATURE pos

N FEATURE neg

log max Conc tested

FEATURE neg logIC50 MEAN

FEATURE pos logIC50 MEAN

FEATURE deltaMEAN IC50

FEATURE IC50 effectSize

FEATURE neg Glass delta

FEATURE pos Glass delta

ANOVA FEATURE pval

Tissue ANOVA pval

MSI ANOVA pval

ANOVA FEATURE FDR %

a2

TP53_mut

136

1

1

Mitomycin C

DNA crosslinker

15

4

2.77

1.11

-1.84

-2.94

2.8 **

4.1 **

2.7 **

9.94e-05

NA

NA

11

a5

TP53_mut

133

1

1

Doxorubicin

DNA intercalating

15

4

0.0237

0.221

-2.69

-2.91

2.3 **

2 **

2.4 **

7.13e-04

NA

NA

24

a6

TP53_mut

135

1

1

Gemcitabine

DNA replication

15

4

0.0237

1.46

-3.36

-4.82

2.3 **

3.5 **

2.2 **

7.27e-04

NA

NA

24

All-tests volcano plot