ANOVA BRCA specific result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 12:18:57 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: BRCA specific


Individual drug analysis: 1003


Drug details and screening numbers

Drug Name: Camptothecin
Drug ID: 1003
Synonyms: 7-Ethyl-10-Hydroxy-Camptothecin,SN-38
Brand name: SN-38
Target: TOP1

Number of cell lines screened: 849
Screening concentration range(s): 0.000390625 to 0.1 uM


Statistically significant associations identified = 1

association id

FEATURE

Drug id

Propr

Public

Drug Name

Drug Target

N FEATURE pos

N FEATURE neg

log max Conc tested

FEATURE neg logIC50 MEAN

FEATURE pos logIC50 MEAN

FEATURE deltaMEAN IC50

FEATURE IC50 effectSize

FEATURE neg Glass delta

FEATURE pos Glass delta

ANOVA FEATURE pval

Tissue ANOVA pval

MSI ANOVA pval

ANOVA FEATURE FDR %

a15

gain_cnaBRCA26_(CDK12,ERBB2,MED24)

1003

1

1

Camptothecin

TOP1

15

30

-2.3

-3.11

-1.37

1.73

1.3 *

1.5 *

1 .

2.35e-04

NA

NA

18

All-tests volcano plot