ANOVA BRCA specific result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 12:18:57 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: BRCA specific


Individual drug analysis: 1057


Drug details and screening numbers

Drug Name: NVP-BEZ235
Drug ID: 1057
Synonyms: BEZ235
Brand name:
Target: PI3K (Class 1) and MTORC1/2

Number of cell lines screened: 842
Screening concentration range(s): 0.0009765625 to 0.25 uM and 0.0078125 to 2 uM


Statistically significant associations identified = 1

association id

FEATURE

Drug id

Propr

Public

Drug Name

Drug Target

N FEATURE pos

N FEATURE neg

log max Conc tested

FEATURE neg logIC50 MEAN

FEATURE pos logIC50 MEAN

FEATURE deltaMEAN IC50

FEATURE IC50 effectSize

FEATURE neg Glass delta

FEATURE pos Glass delta

ANOVA FEATURE pval

Tissue ANOVA pval

MSI ANOVA pval

ANOVA FEATURE FDR %

a37

gain_cnaBRCA62

1057

1

1

NVP-BEZ235

PI3K (Class 1) and MTORC1/2

7

36

-1.386, 0.693

-2.43

-1.16

1.26

1.5 *

1.6 *

1.3 *

6.89e-04

NA

NA

22

All-tests volcano plot