ANOVA BRCA specific result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 12:18:57 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: BRCA specific


Individual drug analysis: 119


Drug details and screening numbers

Drug Name: Lapatinib
Drug ID: 119
Synonyms: Tykerb, Tyverb
Brand name: Tykerb, Tyverb
Target: ERBB2, EGFR

Number of cell lines screened: 398
Screening concentration range(s): 0.0078125 to 2 uM


Statistically significant associations identified = 2

association id

FEATURE

Drug id

Propr

Public

Drug Name

Drug Target

N FEATURE pos

N FEATURE neg

log max Conc tested

FEATURE neg logIC50 MEAN

FEATURE pos logIC50 MEAN

FEATURE deltaMEAN IC50

FEATURE IC50 effectSize

FEATURE neg Glass delta

FEATURE pos Glass delta

ANOVA FEATURE pval

Tissue ANOVA pval

MSI ANOVA pval

ANOVA FEATURE FDR %

a2

gain_cnaBRCA27_(CLTC,PPM1D)

119

1

1

Lapatinib

ERBB2, EGFR

3

10

0.693

2.54

-2.2

-4.74

5.7 **

6.1 **

4.6 **

2.92e-06

NA

NA

1.7

a12

gain_cnaBRCA26_(CDK12,ERBB2,MED24)

119

1

1

Lapatinib

ERBB2, EGFR

4

9

0.693

2.66

-1.31

-3.97

3.3 **

5.6 **

2 **

1.8e-04

NA

NA

16

All-tests volcano plot