ANOVA BRCA specific result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 12:18:57 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: BRCA specific


Individual drug analysis: 1377


Drug details and screening numbers

Drug Name: Afatinib (rescreen)
Drug ID: 1377
Synonyms: Tovok, BIBW2992
Brand name: Gilotrif
Target: ERBB2, EGFR

Number of cell lines screened: 915
Screening concentration range(s): 0.0390625 to 10 uM


Statistically significant associations identified = 1

association id

FEATURE

Drug id

Propr

Public

Drug Name

Drug Target

N FEATURE pos

N FEATURE neg

log max Conc tested

FEATURE neg logIC50 MEAN

FEATURE pos logIC50 MEAN

FEATURE deltaMEAN IC50

FEATURE IC50 effectSize

FEATURE neg Glass delta

FEATURE pos Glass delta

ANOVA FEATURE pval

Tissue ANOVA pval

MSI ANOVA pval

ANOVA FEATURE FDR %

a1

gain_cnaBRCA26_(CDK12,ERBB2,MED24)

1377

1

1

Afatinib (rescreen)

ERBB2, EGFR

15

32

2.3

3.83

0.704

-3.13

2.3 **

2.3 **

2.4 **

2.07e-09

NA

NA

0.0024

All-tests volcano plot