ANOVA BRCA specific result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 12:18:57 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: BRCA specific


Individual drug analysis: 1526


Drug details and screening numbers

Drug Name: RDEA119 (rescreen)
Drug ID: 1526
Synonyms:
Brand name:
Target: MAP2K1 (MEK1), MAP2K2 (MEK2)

Number of cell lines screened: 878
Screening concentration range(s): 0.01953125 to 5 uM


Statistically significant associations identified = 1

association id

FEATURE

Drug id

Propr

Public

Drug Name

Drug Target

N FEATURE pos

N FEATURE neg

log max Conc tested

FEATURE neg logIC50 MEAN

FEATURE pos logIC50 MEAN

FEATURE deltaMEAN IC50

FEATURE IC50 effectSize

FEATURE neg Glass delta

FEATURE pos Glass delta

ANOVA FEATURE pval

Tissue ANOVA pval

MSI ANOVA pval

ANOVA FEATURE FDR %

a36

gain_cnaBRCA31

1526

1

1

RDEA119 (rescreen)

MAP2K1 (MEK1), MAP2K2 (MEK2)

13

30

1.61

2.46

4.07

1.61

1.2 *

1.1 *

1.9 *

6.69e-04

NA

NA

22

All-tests volcano plot