ANOVA BRCA specific result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 12:18:57 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: BRCA specific


Individual drug analysis: 275


Drug details and screening numbers

Drug Name: I-BET
Drug ID: 275
Synonyms: GSK525762A, (S)-À2-À(6-À(4-Àchlorophenyl)-À8-Àmethoxy-À4H-Àbenzo[f][1,À2,À4]triazolo[4,À3-Àa][1,À4]diazepin-À4-Àyl)-ÀN-Àethylacetamide
Brand name:
Target: BRD2, BRD3, BRD4

Number of cell lines screened: 920
Screening concentration range(s): 0.078125 to 20 uM


Statistically significant associations identified = 1

association id

FEATURE

Drug id

Propr

Public

Drug Name

Drug Target

N FEATURE pos

N FEATURE neg

log max Conc tested

FEATURE neg logIC50 MEAN

FEATURE pos logIC50 MEAN

FEATURE deltaMEAN IC50

FEATURE IC50 effectSize

FEATURE neg Glass delta

FEATURE pos Glass delta

ANOVA FEATURE pval

Tissue ANOVA pval

MSI ANOVA pval

ANOVA FEATURE FDR %

a34

loss_cnaBRCA18

275

1

1

I-BET

BRD2, BRD3, BRD4

16

33

3

4.48

3.13

-1.35

1.1 *

1.1 *

1.3 *

6.4e-04

NA

NA

22

All-tests volcano plot