ANOVA BRCA specific result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 12:19:00 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: BRCA specific


Individual Feature analysis: ASH1L_mut


Feature details and cell panel numbers

Binary feature equal to 1 for samples harboring mutations in ASH1L

Number of cell lines positive for this feature: 3


Statistically significant associations identified = 3

association id

FEATURE

Drug id

Propr

Public

Drug Name

Drug Target

N FEATURE pos

N FEATURE neg

log max Conc tested

FEATURE neg logIC50 MEAN

FEATURE pos logIC50 MEAN

FEATURE deltaMEAN IC50

FEATURE IC50 effectSize

FEATURE neg Glass delta

FEATURE pos Glass delta

ANOVA FEATURE pval

Tissue ANOVA pval

MSI ANOVA pval

ANOVA FEATURE FDR %

a9

ASH1L_mut

147

1

1

NSC-87877

PTPN6 (SHP-1), PTPN11 (SHP-2)

3

44

2.77

5.15

2.94

-2.21

2.5 **

2.6 **

1.6 *

1.08e-04

NA

NA

14

a14

ASH1L_mut

170

1

1

Shikonin

unknown

3

44

2.77

0.161

-2.3

-2.47

2.4 **

2.4 **

11 **

2.13e-04

NA

NA

18

a30

ASH1L_mut

167

1

1

OSU-03012

PDPK1 (PDK1)

3

45

2.77

2.39

0.062

-2.33

2.2 **

2.3 **

1.8 *

5.03e-04

NA

NA

19

All-tests volcano plot