ANOVA LUAD specific result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 12:35:11 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: LUAD specific


Individual drug analysis: 1498


Drug details and screening numbers

Drug Name: AZD6244
Drug ID: 1498
Synonyms:
Brand name:
Target: MAP2K1 (MEK1), MAP2K2 (MEK2)

Number of cell lines screened: 921
Screening concentration range(s): 0.015625 to 4 uM


Statistically significant associations identified = 1

association id

FEATURE

Drug id

Propr

Public

Drug Name

Drug Target

N FEATURE pos

N FEATURE neg

log max Conc tested

FEATURE neg logIC50 MEAN

FEATURE pos logIC50 MEAN

FEATURE deltaMEAN IC50

FEATURE IC50 effectSize

FEATURE neg Glass delta

FEATURE pos Glass delta

ANOVA FEATURE pval

Tissue ANOVA pval

MSI ANOVA pval

ANOVA FEATURE FDR %

a7

KRAS_mut

1498

1

1

AZD6244

MAP2K1 (MEK1), MAP2K2 (MEK2)

20

42

1.39

2.22

0.559

-1.67

1.3 *

1.3 *

1.3 *

6.89e-06

NA

NA

0.85

All-tests volcano plot