ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:09 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual drug analysis: 1024


Drug details and screening numbers

Drug Name: CEP-701
Drug ID: 1024
Synonyms: CEP-701
Brand name: Lestaurtinib
Target: FLT3, JAK2, NTRK1, RET

Number of cell lines screened: 849
Screening concentration range(s): 0.0078125 to 2 uM


Statistically significant associations identified = 4

association id	FEATURE	Drug id	Propr	Public	Drug Name	Drug Target	N FEATURE pos	N FEATURE neg	log max Conc tested	FEATURE neg logIC50 MEAN	FEATURE pos logIC50 MEAN	FEATURE deltaMEAN IC50	FEATURE IC50 effectSize	FEATURE neg Glass delta	FEATURE pos Glass delta	ANOVA FEATURE pval	Tissue ANOVA pval	MSI ANOVA pval	ANOVA FEATURE FDR %
a141	gain_cnaPANCAN301_(CDK12,ERBB2,MED24)	1024	1	1	CEP-701	FLT3, JAK2, NTRK1, RET	46	800	0.693	-0.697	0.68	1.38	0.93 .	0.93 .	0.9 .	3.36e-05	3.66e-28	9e-02	3.9
a248	HGF_mut	1024	1	1	CEP-701	FLT3, JAK2, NTRK1, RET	4	842	0.693	-0.637	2.43	3.06	2 **	2 **	2.1 **	1.54e-04	4.81e-28	9.05e-02	10
a377	loss_cnaPANCAN26	1024	1	1	CEP-701	FLT3, JAK2, NTRK1, RET	238	608	0.693	-0.77	-0.246	0.524	0.35	0.36	0.33	3.85e-04	5.65e-28	9.09e-02	17
a397	MYC_mut	1024	1	1	CEP-701	FLT3, JAK2, NTRK1, RET	5	841	0.693	-0.628	0.375	1	0.66 .	0.67 .	0.38	4.47e-04	5.8e-28	9.09e-02	19

All-tests volcano plot