ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:07 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual drug analysis: 1032


Drug details and screening numbers

Drug Name: Afatinib
Drug ID: 1032
Synonyms: Tovok, BIBW2992
Brand name: Gilotrif
Target: ERBB2, EGFR

Number of cell lines screened: 849
Screening concentration range(s): 0.001953125 to 0.5 uM


Statistically significant associations identified = 2

association id	FEATURE	Drug id	Propr	Public	Drug Name	Drug Target	N FEATURE pos	N FEATURE neg	log max Conc tested	FEATURE neg logIC50 MEAN	FEATURE pos logIC50 MEAN	FEATURE deltaMEAN IC50	FEATURE IC50 effectSize	FEATURE neg Glass delta	FEATURE pos Glass delta	ANOVA FEATURE pval	Tissue ANOVA pval	MSI ANOVA pval	ANOVA FEATURE FDR %
a37	gain_cnaPANCAN301_(CDK12,ERBB2,MED24)	1032	1	1	Afatinib	ERBB2, EGFR	46	800	-0.693	0.923	-0.749	-1.67	1.2 *	1.2 *	0.82 .	4.73e-08	3.03e-33	1.82e-01	0.021
a266	gain_cnaPANCAN124_(EGFR)	1032	1	1	Afatinib	ERBB2, EGFR	87	759	-0.693	0.913	0.131	-0.782	0.53 .	0.58 .	0.35	1.78e-04	1.63e-32	1.86e-01	11

All-tests volcano plot