ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:11 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual drug analysis: 1133


Drug details and screening numbers

Drug Name: JNJ-26854165
Drug ID: 1133
Synonyms:
Brand name: Serdemetan
Target: MDM2

Number of cell lines screened: 918
Screening concentration range(s): 0.0390625 to 10 uM


Statistically significant associations identified = 2

association id

FEATURE

Drug id

Propr

Public

Drug Name

Drug Target

N FEATURE pos

N FEATURE neg

log max Conc tested

FEATURE neg logIC50 MEAN

FEATURE pos logIC50 MEAN

FEATURE deltaMEAN IC50

FEATURE IC50 effectSize

FEATURE neg Glass delta

FEATURE pos Glass delta

ANOVA FEATURE pval

Tissue ANOVA pval

MSI ANOVA pval

ANOVA FEATURE FDR %

a353

loss_cnaPANCAN266

1133

1

1

JNJ-26854165

MDM2

8

907

2.3

2.71

4

1.29

1.3 *

1.3 *

1.9 *

3.56e-04

2.02e-18

4.23e-01

17

a400

loss_cnaPANCAN187

1133

1

1

JNJ-26854165

MDM2

8

907

2.3

2.71

3.93

1.22

1.2 *

1.2 *

1.6 *

4.58e-04

2.08e-18

4.23e-01

19

All-tests volcano plot