ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:10 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual drug analysis: 147


Drug details and screening numbers

Drug Name: NSC-87877
Drug ID: 147
Synonyms:
Brand name:
Target: PTPN6 (SHP-1), PTPN11 (SHP-2)

Number of cell lines screened: 880
Screening concentration range(s): 0.0625 to 16 uM


Statistically significant associations identified = 2

association id

FEATURE

Drug id

Propr

Public

Drug Name

Drug Target

N FEATURE pos

N FEATURE neg

log max Conc tested

FEATURE neg logIC50 MEAN

FEATURE pos logIC50 MEAN

FEATURE deltaMEAN IC50

FEATURE IC50 effectSize

FEATURE neg Glass delta

FEATURE pos Glass delta

ANOVA FEATURE pval

Tissue ANOVA pval

MSI ANOVA pval

ANOVA FEATURE FDR %

a216

SRGAP1_mut

147

1

1

NSC-87877

PTPN6 (SHP-1), PTPN11 (SHP-2)

6

871

2.77

4.91

3.61

-1.3

1.5 *

1.5 *

1 *

1.04e-04

3.58e-06

5.05e-01

7.9

a238

MAP3K4_mut

147

1

1

NSC-87877

PTPN6 (SHP-1), PTPN11 (SHP-2)

7

870

2.77

4.92

3.66

-1.26

1.4 *

1.4 *

1.4 *

1.28e-04

3.62e-06

5.05e-01

8.9

All-tests volcano plot