ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:11
iorio@ebi.ac.uk


Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual drug analysis: 201


Drug details and screening numbers

Drug Name: Epothilone B
Drug ID: 201
Synonyms: GNF-PF-193
Brand name: EPO906 (ixabepilone,Patupilone)
Target: Microtubules

Number of cell lines screened: 875
Screening concentration range(s): 0.000125 to 0.032 uM


Statistically significant associations identified = 3
association id
FEATURE
Drug id
Propr
Public
Drug Name
Drug Target
N FEATURE pos
N FEATURE neg
log max Conc tested
FEATURE neg logIC50 MEAN
FEATURE pos logIC50 MEAN
FEATURE deltaMEAN IC50
FEATURE IC50 effectSize
FEATURE neg Glass delta
FEATURE pos Glass delta
ANOVA FEATURE pval
Tissue ANOVA pval
MSI ANOVA pval
ANOVA FEATURE FDR %
a294
loss_cnaPANCAN232
201
1
1
Epothilone B
Microtubules
42
830
-3.44
-4.96
-3.79
1.18
0.63 .
0.63 .
0.62 .
2.23e-04
2.76e-07
1.24e-01
13
a299
gain_cnaPANCAN411_(BLM,CRTC3,FANCI,IDH2,NR2F2,PCSK6)
201
1
1
Epothilone B
Microtubules
26
846
-3.44
-4.94
-3.69
1.25
0.67 .
0.67 .
0.61 .
2.4e-04
2.77e-07
1.24e-01
13
a310
loss_cnaPANCAN227, loss_cnaPANCAN228
201
1
1
Epothilone B
Microtubules
27
845
-3.44
-4.95
-3.6
1.35
0.73 .
0.73 .
0.65 .
2.72e-04
2.79e-07
1.24e-01
14


All-tests volcano plot