ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:08 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual drug analysis: 45


Drug details and screening numbers

Drug Name: Z-LLNle-CHO
Drug ID: 45
Synonyms: Z-L-Norleucine-CHO
Brand name: na
Target: g-secretase

Number of cell lines screened: 401
Screening concentration range(s): 0.01 to 2.56 uM


Statistically significant associations identified = 2

association id

FEATURE

Drug id

Propr

Public

Drug Name

Drug Target

N FEATURE pos

N FEATURE neg

log max Conc tested

FEATURE neg logIC50 MEAN

FEATURE pos logIC50 MEAN

FEATURE deltaMEAN IC50

FEATURE IC50 effectSize

FEATURE neg Glass delta

FEATURE pos Glass delta

ANOVA FEATURE pval

Tissue ANOVA pval

MSI ANOVA pval

ANOVA FEATURE FDR %

a117

gain_cnaPANCAN140_(FANCG)

45

1

1

Z-LLNle-CHO

g-secretase

5

395

0.94

0.755

2.84

2.08

1.7 *

1.7 *

4.6 **

1.92e-05

1.55e-11

7.89e-02

2.7

a497

gain_cnaPANCAN411_(BLM,CRTC3,FANCI,IDH2,NR2F2,PCSK6)

45

1

1

Z-LLNle-CHO

g-secretase

11

389

0.94

0.746

2.01

1.26

1 *

1 *

0.82 .

7.06e-04

2.96e-11

8.16e-02

23

All-tests volcano plot