ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:11 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual drug analysis: 60


Drug details and screening numbers

Drug Name: BI-2536
Drug ID: 60
Synonyms: KIN001-124
Brand name: NPK33-1-98-1
Target: PLK1, PLK2, PLK3

Number of cell lines screened: 400
Screening concentration range(s): 0.001 to 0.256 uM


Statistically significant associations identified = 2

association id

FEATURE

Drug id

Propr

Public

Drug Name

Drug Target

N FEATURE pos

N FEATURE neg

log max Conc tested

FEATURE neg logIC50 MEAN

FEATURE pos logIC50 MEAN

FEATURE deltaMEAN IC50

FEATURE IC50 effectSize

FEATURE neg Glass delta

FEATURE pos Glass delta

ANOVA FEATURE pval

Tissue ANOVA pval

MSI ANOVA pval

ANOVA FEATURE FDR %

a319

PBRM1_mut

60

1

1

BI-2536

PLK1, PLK2, PLK3

7

392

-1.36

-1.98

0.0914

2.07

1.3 *

1.3 *

1.4 *

2.83e-04

2.71e-03

6.92e-01

15

a490

STAG2_mut

60

1

1

BI-2536

PLK1, PLK2, PLK3

12

387

-1.36

-2

-0.242

1.75

1.1 *

1.1 *

0.9 .

6.94e-04

2.87e-03

6.93e-01

23

All-tests volcano plot