Genomics of Drug Sensitivity in Cancer

We have characterised 1000 human cancer cell lines and screened them with 100s of compounds.
On this website, you will find drug response data and genomic markers of sensitivity.

Our website and results are part of an ongoing research project. These webpages are updated frequently and our results are not final or complete.

What's new?

Release 8.4 (July 2022)

The GDSC datasets have been updated with an additional 130612 IC50s. There are 36 previously unreleased compounds in the new GDSC1 dataset. The GDSC2 dataset now covers an extra 160 cell lines and 99 compounds, with 80% more IC50s than release 8.3.


from 2010 to 2015 ✓ NEW
970 Cell lines 969 Cell lines
403 Compounds 297 Compounds
333292 IC50s 243466 IC50s
Resazurin or Syto60 CellTitreGlo
72 hours 72 hours

Key Publications

Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells.
Yang et al., (2013) Nucl. Acids Res. 41 (Database issue): D955 - D961. (PMID:23180760 )

A landscape of pharmacogenomic interactions in cancer
Iorio et al., (2016). Cell, Volume 166, Issue 3, 740 - 754 (PMID:27397505 )

Systematic identification of genomic markers of drug sensitivity in cancer cells
Garnett et al., (2012) Nature volume 483, pages 570 – 575 (PMID:27397505 )

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