Genomics of Drug Sensitivity in Cancer

We have characterised 1000 human cancer cell lines and screened them with 100s of compounds.
On this website, you will find drug response data and genomic markers of sensitivity.


Our website and results are part of an ongoing research project. These webpages are updated frequently and our results are not final or complete.

What's new?

Release 8.1 (Oct 2019)

The GDSC database now contains data for an extra 187 drugs and more than 160,000 new IC50s - an increase of ~70% compared to release 7.0. Two datasets are available: GDSC1 updates our previous screening results; and GDSC2 uses the latest improved screening technology.

Datasets

GDSC1 GDSC2
Age  
from 2010 to 2015 ✓ NEW
Size  
987 Cell lines 809 Cell lines
320 Compounds 175 Compounds
267284 IC50s 118428 IC50s
Assay  
Resazurin or Syto60 CellTitreGlo
Duration  
72 hours 72 hours

Key Publications

Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells.
Yang et al., (2013) Nucl. Acids Res. 41 (Database issue): D955 - D961. (PMID:23180760 )

A landscape of pharmacogenomic interactions in cancer
Iorio et al., (2016). Cell, Volume 166, Issue 3, 740 - 754 (PMID:27397505 )

Systematic identification of genomic markers of drug sensitivity in cancer cells
Garnett et al., (2012) Nature volume 483, pages 570 – 575 (PMID:27397505 )

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