Genomics of Drug Sensitivity in Cancer

We have characterised 1000 human cancer cell lines and screened them with 100s of compounds.
On this website, you will find drug response data and genomic markers of sensitivity.

Our website and results are part of an ongoing research project. These webpages are updated frequently and our results are not final or complete.

What's new?

Release 8.2 (Feb 2020)

Release 8.2 adds 47 compounds to the GDSC1 dataset and 23 compounds to the GDSC2 dataset. In total there are 60434 new IC50s, 15% more than in release 8.1. Two datasets are available: GDSC1 updates our previous screening results; and GDSC2 uses the latest improved screening technology.


from 2010 to 2015 ✓ NEW
987 Cell lines 809 Cell lines
367 Compounds 198 Compounds
310904 IC50s 135242 IC50s
Resazurin or Syto60 CellTitreGlo
72 hours 72 hours

Key Publications

Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells.
Yang et al., (2013) Nucl. Acids Res. 41 (Database issue): D955 - D961. (PMID:23180760 )

A landscape of pharmacogenomic interactions in cancer
Iorio et al., (2016). Cell, Volume 166, Issue 3, 740 - 754 (PMID:27397505 )

Systematic identification of genomic markers of drug sensitivity in cancer cells
Garnett et al., (2012) Nature volume 483, pages 570 – 575 (PMID:27397505 )

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