Genomics of Drug Sensitivity in Cancer

We have characterised 1000 human cancer cell lines and screened them with 100s of compounds.
On this website, you will find drug response data and genomic markers of sensitivity.


Our website and results are part of an ongoing research project. These webpages are updated frequently and our results are not final or complete.

What's new?

Release 8.3 (June 2020)

The functionality of the Genomics of Drug Sensitivity in Cancer database has now been enhanced with two new data visualisations. The Combined Analyses Volcano Plot overlays all tissue specific and pan-cancer associations to visualize significant biomarker associations across all context-specific ANOVA analyses. Compare compound plots the correlation of dose response results (IC50 or AUC ) between different drugs across the cell line set.

Datasets

GDSC1 GDSC2
Age  
from 2010 to 2015 ✓ NEW
Size  
987 Cell lines 809 Cell lines
367 Compounds 198 Compounds
310904 IC50s 135242 IC50s
Assay  
Resazurin or Syto60 CellTitreGlo
Duration  
72 hours 72 hours

Key Publications

Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells.
Yang et al., (2013) Nucl. Acids Res. 41 (Database issue): D955 - D961. (PMID:23180760 )

A landscape of pharmacogenomic interactions in cancer
Iorio et al., (2016). Cell, Volume 166, Issue 3, 740 - 754 (PMID:27397505 )

Systematic identification of genomic markers of drug sensitivity in cancer cells
Garnett et al., (2012) Nature volume 483, pages 570 – 575 (PMID:27397505 )

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