We have characterised 1000 human cancer cell lines and screened them with 100s of compounds.
On this website, you will find drug response data and genomic markers of sensitivity.
Our website and results are part of an ongoing research project. These
webpages are updated frequently
and our results are not final or complete.
What's new?
Release 8.3 (June 2020)
The functionality of the Genomics of Drug Sensitivity in Cancer database has now been
enhanced with two new data visualisations. The Combined Analyses Volcano Plot overlays
all tissue specific and pan-cancer associations to visualize significant biomarker
associations across all context-specific ANOVA analyses. Compare compound plots the
correlation of dose response results (IC50 or AUC ) between different drugs across
the cell line set.
Datasets
GDSC1 |
GDSC2 |
from 2010 to 2015 |
✓ NEW |
987 Cell lines |
809 Cell lines |
367 Compounds |
198 Compounds |
310904 IC50s |
135242 IC50s |
Resazurin or Syto60 |
CellTitreGlo |
72 hours |
72 hours |
Key Publications
Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells.
Yang et al., (2013) Nucl. Acids Res. 41 (Database issue): D955 - D961. (PMID:23180760
)
A landscape of pharmacogenomic interactions in cancer
Iorio et al., (2016). Cell, Volume 166, Issue 3, 740 - 754
(PMID:27397505
)
Systematic identification of genomic markers of drug sensitivity in cancer
cells
Garnett et al., (2012) Nature volume 483, pages 570 – 575 (PMID:27397505
)