ANOVA BRCA specific result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 12:18:57 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: BRCA specific


Individual drug analysis: 1011


Drug details and screening numbers

Drug Name: ABT-263
Drug ID: 1011
Synonyms:
Brand name:
Target: BCL2, BCL2L1, BCL2L2

Number of cell lines screened: 849
Screening concentration range(s): 0.0078125 to 2 uM


Statistically significant associations identified = 2

association id

FEATURE

Drug id

Propr

Public

Drug Name

Drug Target

N FEATURE pos

N FEATURE neg

log max Conc tested

FEATURE neg logIC50 MEAN

FEATURE pos logIC50 MEAN

FEATURE deltaMEAN IC50

FEATURE IC50 effectSize

FEATURE neg Glass delta

FEATURE pos Glass delta

ANOVA FEATURE pval

Tissue ANOVA pval

MSI ANOVA pval

ANOVA FEATURE FDR %

a8

loss_cnaBRCA34

1011

1

1

ABT-263

BCL2, BCL2L1, BCL2L2

5

38

0.693

2.03

-0.937

-2.96

2.2 **

2.2 **

1.6 *

5.06e-05

NA

NA

7.3

a40

loss_cnaBRCA33

1011

1

1

ABT-263

BCL2, BCL2L1, BCL2L2

5

38

0.693

1.98

-0.548

-2.52

1.7 *

1.7 *

1.7 *

8.19e-04

NA

NA

24

All-tests volcano plot