ANOVA BRCA specific result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 12:19:00 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: BRCA specific


Individual Feature analysis: loss_cnaBRCA33


Feature details and cell panel numbers

Binary feature equal to 1 for samples having the genomic region(s) cnaBRCA33 deleted (see genomic region decoding file for further infos on this region)

Number of cell lines positive for this feature: 6


Statistically significant associations identified = 3

association id

FEATURE

Drug id

Propr

Public

Drug Name

Drug Target

N FEATURE pos

N FEATURE neg

log max Conc tested

FEATURE neg logIC50 MEAN

FEATURE pos logIC50 MEAN

FEATURE deltaMEAN IC50

FEATURE IC50 effectSize

FEATURE neg Glass delta

FEATURE pos Glass delta

ANOVA FEATURE pval

Tissue ANOVA pval

MSI ANOVA pval

ANOVA FEATURE FDR %

a6

loss_cnaBRCA33

206

1

1

Ruxolitinib

JAK1, JAK2, TYK2

6

43

1.6563, 0.0237

4.51

3.4

-1.11

2 **

2.2 **

1.3 *

2.63e-05

NA

NA

5.1

a18

loss_cnaBRCA33

312

1

1

AV-951

VEGFR

6

42

-2.06

0.752

-0.207

-0.959

1.7 *

1.8 *

1.2 *

2.85e-04

NA

NA

18

a40

loss_cnaBRCA33

1011

1

1

ABT-263

BCL2, BCL2L1, BCL2L2

5

38

0.693

1.98

-0.548

-2.52

1.7 *

1.7 *

1.7 *

8.19e-04

NA

NA

24

All-tests volcano plot