ANOVA BRCA specific result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 12:18:57 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: BRCA specific


Individual drug analysis: 206


Drug details and screening numbers

Drug Name: Ruxolitinib
Drug ID: 206
Synonyms: INCB-18424
Brand name: Jakafi
Target: JAK1, JAK2, TYK2

Number of cell lines screened: 925
Screening concentration range(s): 0.02046875 to 5.24 uM and 0.004 to 1.024 uM


Statistically significant associations identified = 1

association id

FEATURE

Drug id

Propr

Public

Drug Name

Drug Target

N FEATURE pos

N FEATURE neg

log max Conc tested

FEATURE neg logIC50 MEAN

FEATURE pos logIC50 MEAN

FEATURE deltaMEAN IC50

FEATURE IC50 effectSize

FEATURE neg Glass delta

FEATURE pos Glass delta

ANOVA FEATURE pval

Tissue ANOVA pval

MSI ANOVA pval

ANOVA FEATURE FDR %

a6

loss_cnaBRCA33

206

1

1

Ruxolitinib

JAK1, JAK2, TYK2

6

43

1.6563, 0.0237

4.51

3.4

-1.11

2 **

2.2 **

1.3 *

2.63e-05

NA

NA

5.1

All-tests volcano plot