ANOVA BRCA specific result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 12:18:57 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: BRCA specific


Individual drug analysis: 1268


Drug details and screening numbers

Drug Name: XAV 939
Drug ID: 1268
Synonyms: NVP-XAV 939
Brand name:
Target: TNKS1 (tankyrase-1)

Number of cell lines screened: 919
Screening concentration range(s): 0.01953125 to 5 uM


Statistically significant associations identified = 2

association id

FEATURE

Drug id

Propr

Public

Drug Name

Drug Target

N FEATURE pos

N FEATURE neg

log max Conc tested

FEATURE neg logIC50 MEAN

FEATURE pos logIC50 MEAN

FEATURE deltaMEAN IC50

FEATURE IC50 effectSize

FEATURE neg Glass delta

FEATURE pos Glass delta

ANOVA FEATURE pval

Tissue ANOVA pval

MSI ANOVA pval

ANOVA FEATURE FDR %

a22

gain_cnaBRCA31

1268

1

1

XAV 939

TNKS1 (tankyrase-1)

15

32

1.61

3.35

4.33

0.985

1.2 *

1.2 *

1.3 *

3.94e-04

NA

NA

19

a31

gain_cnaBRCA30_(CRNKL1,FOXA2)

1268

1

1

XAV 939

TNKS1 (tankyrase-1)

5

42

1.61

3.51

4.97

1.46

1.8 *

1.8 *

1.8 *

5.27e-04

NA

NA

20

All-tests volcano plot