ANOVA BRCA specific result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 12:19:00 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: BRCA specific


Individual Feature analysis: gain_cnaBRCA30_(CRNKL1,FOXA2)


Feature details and cell panel numbers

Binary feature equal to 1 for samples having the genomic region(s) cnaBRCA30_(CRNKL1,FOXA2) amplified (see genomic region decoding file for further infos on this region)

Number of cell lines positive for this feature: 6


Statistically significant associations identified = 8

association id	FEATURE	Drug id	Propr	Public	Drug Name	Drug Target	N FEATURE pos	N FEATURE neg	log max Conc tested	FEATURE neg logIC50 MEAN	FEATURE pos logIC50 MEAN	FEATURE deltaMEAN IC50	FEATURE IC50 effectSize	FEATURE neg Glass delta	FEATURE pos Glass delta	ANOVA FEATURE pval	Tissue ANOVA pval	MSI ANOVA pval	ANOVA FEATURE FDR %
a4	gain_cnaBRCA30_(CRNKL1,FOXA2)	204	1	1	Tipifarnib	Farnesyl-transferase (FNTA)	5	43	2.77	1.31	4.24	2.93	2.4 **	2.5 **	1.7 *	6.77e-06	NA	NA	2
a11	gain_cnaBRCA30_(CRNKL1,FOXA2)	180	1	1	Thapsigargin	sarco-endoplasmic reticulum Ca2+-ATPases	4	41	-0.669	-3.89	0.617	4.5	2.2 **	2.2 **	2.2 **	1.53e-04	NA	NA	16
a26	gain_cnaBRCA30_(CRNKL1,FOXA2)	140	1	1	Vinorelbine	Microtubules	5	42	-2.75	-3.88	-1.28	2.59	1.8 *	1.8 *	2 *	4.38e-04	NA	NA	19
a28	gain_cnaBRCA30_(CRNKL1,FOXA2)	1375	1	1	Temozolomide	DNA akylating agent	5	41	3.4	5.78	6.87	1.09	1.8 *	1.8 *	1.5 *	4.74e-04	NA	NA	19
a29	gain_cnaBRCA30_(CRNKL1,FOXA2)	201	1	1	Epothilone B	Microtubules	5	43	-3.44	-4.53	-1.71	2.82	1.8 *	1.8 *	1.9 *	5.01e-04	NA	NA	19
a31	gain_cnaBRCA30_(CRNKL1,FOXA2)	1268	1	1	XAV 939	TNKS1 (tankyrase-1)	5	42	1.61	3.51	4.97	1.46	1.8 *	1.8 *	1.8 *	5.27e-04	NA	NA	20
a32	gain_cnaBRCA30_(CRNKL1,FOXA2)	167	1	1	OSU-03012	PDPK1 (PDK1)	5	43	2.77	2.06	3.89	1.83	1.7 *	1.8 *	1.4 *	5.71e-04	NA	NA	21
a38	gain_cnaBRCA30_(CRNKL1,FOXA2)	1020	1	1	Lenalidomide	TNFA	5	40	1.61	4.13	5.22	1.08	1.7 *	1.8 *	1.4 *	7.3e-04	NA	NA	22

All-tests volcano plot