ANOVA BRCA specific result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 12:18:57 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: BRCA specific


Individual drug analysis: 204


Drug details and screening numbers

Drug Name: Tipifarnib
Drug ID: 204
Synonyms:
Brand name: Zarnestra,IND58359,R115777
Target: Farnesyl-transferase (FNTA)

Number of cell lines screened: 873
Screening concentration range(s): 0.0625 to 16 uM


Statistically significant associations identified = 2

association id

FEATURE

Drug id

Propr

Public

Drug Name

Drug Target

N FEATURE pos

N FEATURE neg

log max Conc tested

FEATURE neg logIC50 MEAN

FEATURE pos logIC50 MEAN

FEATURE deltaMEAN IC50

FEATURE IC50 effectSize

FEATURE neg Glass delta

FEATURE pos Glass delta

ANOVA FEATURE pval

Tissue ANOVA pval

MSI ANOVA pval

ANOVA FEATURE FDR %

a4

gain_cnaBRCA30_(CRNKL1,FOXA2)

204

1

1

Tipifarnib

Farnesyl-transferase (FNTA)

5

43

2.77

1.31

4.24

2.93

2.4 **

2.5 **

1.7 *

6.77e-06

NA

NA

2

a13

gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6)

204

1

1

Tipifarnib

Farnesyl-transferase (FNTA)

7

41

2.77

1.3

3.48

2.18

1.7 *

1.8 *

1.2 *

1.81e-04

NA

NA

16

All-tests volcano plot