ANOVA COREAD specific result package
Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 12:22:40 iorio@ebi.ac.uk
Drug Domain: GDSC1000_paper_set, Analysis Domain: COREAD specific
Individual drug analysis: 272
Drug details and screening numbers
Drug Name: AR-42
Drug ID: 272
Synonyms: HDAC-42
Brand name:
Target: HDAC
Number of cell lines screened: 913
Screening concentration range(s): 0.02 to 5.12 uM
Statistically significant associations identified = 4
| association id |
FEATURE |
Drug id |
Propr |
Public |
Drug Name |
Drug Target |
N FEATURE pos |
N FEATURE neg |
log max Conc tested |
FEATURE neg logIC50 MEAN |
FEATURE pos logIC50 MEAN |
FEATURE deltaMEAN IC50 |
FEATURE IC50 effectSize |
FEATURE neg Glass delta |
FEATURE pos Glass delta |
ANOVA FEATURE pval |
Tissue ANOVA pval |
MSI ANOVA pval |
ANOVA FEATURE FDR % |
a1 |
CLSPN_mut |
272 |
1 |
1 |
AR-42 |
HDAC |
3 |
42 |
1.63 |
-0.48 |
3.33 |
3.81 |
3.7 ** |
4.3 ** |
1.5 * |
9.29e-08 |
NA |
4e-02 |
0.11 |
a4 |
CNOT1_mut |
272 |
1 |
1 |
AR-42 |
HDAC |
3 |
42 |
1.63 |
-0.457 |
3.01 |
3.47 |
3.2 ** |
3.8 ** |
1.1 * |
2.85e-06 |
NA |
5.69e-02 |
1.3 |
a7 |
CDK12_mut |
272 |
1 |
1 |
AR-42 |
HDAC |
3 |
42 |
1.63 |
-0.448 |
2.88 |
3.33 |
3 ** |
3.7 ** |
1 * |
8.73e-06 |
NA |
6.32e-02 |
2.3 |
a11 |
ASXL2_mut |
272 |
1 |
1 |
AR-42 |
HDAC |
4 |
41 |
1.63 |
-0.477 |
2.35 |
2.82 |
2.5 ** |
3.1 ** |
1 * |
3.27e-05 |
NA |
7.12e-02 |
5.5 |
All-tests volcano plot
