ANOVA COREAD specific result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 12:22:44 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: COREAD specific


Individual Feature analysis: CNOT1_mut


Feature details and cell panel numbers

Binary feature equal to 1 for samples harboring mutations in CNOT1

Number of cell lines positive for this feature: 3


Statistically significant associations identified = 3

association id

FEATURE

Drug id

Propr

Public

Drug Name

Drug Target

N FEATURE pos

N FEATURE neg

log max Conc tested

FEATURE neg logIC50 MEAN

FEATURE pos logIC50 MEAN

FEATURE deltaMEAN IC50

FEATURE IC50 effectSize

FEATURE neg Glass delta

FEATURE pos Glass delta

ANOVA FEATURE pval

Tissue ANOVA pval

MSI ANOVA pval

ANOVA FEATURE FDR %

a4

CNOT1_mut

272

1

1

AR-42

HDAC

3

42

1.63

-0.457

3.01

3.47

3.2 **

3.8 **

1.1 *

2.85e-06

NA

5.69e-02

1.3

a10

CNOT1_mut

274

1

1

PXD101, Belinostat

HDAC

3

41

3

-0.0325

2.79

2.82

2.7 **

3.3 **

0.91 .

2.95e-05

NA

1.53e-02

5.5

a21

CNOT1_mut

326

1

1

GSK690693

AKT

3

43

2.33

4.29

1.32

-2.98

2.5 **

2.6 **

1.6 *

1.51e-04

NA

2.7e-01

13

All-tests volcano plot