ANOVA COREAD specific result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 12:22:41 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: COREAD specific


Individual drug analysis: 274


Drug details and screening numbers

Drug Name: PXD101, Belinostat
Drug ID: 274
Synonyms:
Brand name:
Target: HDAC

Number of cell lines screened: 896
Screening concentration range(s): 0.078125 to 20 uM


Statistically significant associations identified = 4

association id	FEATURE	Drug id	Propr	Public	Drug Name	Drug Target	N FEATURE pos	N FEATURE neg	log max Conc tested	FEATURE neg logIC50 MEAN	FEATURE pos logIC50 MEAN	FEATURE deltaMEAN IC50	FEATURE IC50 effectSize	FEATURE neg Glass delta	FEATURE pos Glass delta	ANOVA FEATURE pval	Tissue ANOVA pval	MSI ANOVA pval	ANOVA FEATURE FDR %
a6	CLSPN_mut	274	1	1	PXD101, Belinostat	HDAC	3	41	3	-0.0476	3	3.04	3 **	3.6 **	1.1 *	4.15e-06	NA	1.13e-02	1.3
a10	CNOT1_mut	274	1	1	PXD101, Belinostat	HDAC	3	41	3	-0.0325	2.79	2.82	2.7 **	3.3 **	0.91 .	2.95e-05	NA	1.53e-02	5.5
a18	ASXL2_mut	274	1	1	PXD101, Belinostat	HDAC	4	40	3	-0.0562	2.32	2.38	2.2 **	2.8 **	0.89 .	1.27e-04	NA	1.88e-02	12
a23	CDK12_mut	274	1	1	PXD101, Belinostat	HDAC	3	41	3	-0.0143	2.54	2.56	2.3 **	3.1 **	0.75 .	2.14e-04	NA	2.02e-02	17

All-tests volcano plot