ANOVA LAML specific result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 12:30:59 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: LAML specific


Individual drug analysis: 133


Drug details and screening numbers

Drug Name: Doxorubicin
Drug ID: 133
Synonyms: Doxil,Rubex
Brand name: Adriamycin
Target: DNA intercalating

Number of cell lines screened: 875
Screening concentration range(s): 0.004 to 1.024 uM


Statistically significant associations identified = 2

association id

FEATURE

Drug id

Propr

Public

Drug Name

Drug Target

N FEATURE pos

N FEATURE neg

log max Conc tested

FEATURE neg logIC50 MEAN

FEATURE pos logIC50 MEAN

FEATURE deltaMEAN IC50

FEATURE IC50 effectSize

FEATURE neg Glass delta

FEATURE pos Glass delta

ANOVA FEATURE pval

Tissue ANOVA pval

MSI ANOVA pval

ANOVA FEATURE FDR %

a12

NRAS_mut

133

1

1

Doxorubicin

DNA intercalating

7

18

0.0237

-2.47

-0.24

2.23

2 *

2.3 **

1.5 *

3.3e-04

NA

5.1e-01

3.2

a13

TP53_mut

133

1

1

Doxorubicin

DNA intercalating

12

13

0.0237

-2.79

-0.816

1.98

1.7 *

2.4 **

1.4 *

3.45e-04

NA

5.11e-01

3.2

All-tests volcano plot