ANOVA LAML specific result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 12:31:01 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: LAML specific


Individual Feature analysis: TP53_mut


Feature details and cell panel numbers

Binary feature equal to 1 for samples harboring mutations in TP53

Number of cell lines positive for this feature: 15


Statistically significant associations identified = 6

association id	FEATURE	Drug id	Propr	Public	Drug Name	Drug Target	N FEATURE pos	N FEATURE neg	log max Conc tested	FEATURE neg logIC50 MEAN	FEATURE pos logIC50 MEAN	FEATURE deltaMEAN IC50	FEATURE IC50 effectSize	FEATURE neg Glass delta	FEATURE pos Glass delta	ANOVA FEATURE pval	Tissue ANOVA pval	MSI ANOVA pval	ANOVA FEATURE FDR %
a1	TP53_mut	1047	1	1	Nutlin-3a	MDM2	12	11	2.08, 1.39	1.72	3.64	1.93	2.9 **	2.6 **	3.2 **	1.62e-06	NA	9.84e-01	0.2
a8	TP53_mut	11	1	1	Paclitaxel	Microtubules	13	13	-2.28	-4.42	-2.18	2.24	1.7 *	3.6 **	1.3 *	1.94e-04	NA	2.89e-01	3
a11	TP53_mut	53	1	1	CGP-60474	CDK1,CDK2,CDK5,CDK7,CDK9	13	13	-1.36	-2.83	-1.59	1.23	1.7 *	2.7 **	1.3 *	3.01e-04	NA	5.49e-01	3.2
a13	TP53_mut	133	1	1	Doxorubicin	DNA intercalating	12	13	0.0237	-2.79	-0.816	1.98	1.7 *	2.4 **	1.4 *	3.45e-04	NA	5.11e-01	3.2
a25	TP53_mut	134	1	1	Etoposide	TOP2	13	13	2.77	-0.272	2.01	2.28	1.5 *	1.9 *	1.3 *	7.83e-04	NA	3.82e-01	3.8
a26	TP53_mut	179	1	1	5-Fluorouracil	DNA antimetabolite	12	13	3.47	0.461	2.33	1.87	1.4 *	1.7 *	1.2 *	8.35e-04	NA	1.98e-02	3.9

All-tests volcano plot