ANOVA LAML specific result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 12:30:59 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: LAML specific


Individual drug analysis: 134


Drug details and screening numbers

Drug Name: Etoposide
Drug ID: 134
Synonyms: VP-16
Brand name: Etophophos
Target: TOP2

Number of cell lines screened: 885
Screening concentration range(s): 0.0625 to 16 uM


Statistically significant associations identified = 2

association id

FEATURE

Drug id

Propr

Public

Drug Name

Drug Target

N FEATURE pos

N FEATURE neg

log max Conc tested

FEATURE neg logIC50 MEAN

FEATURE pos logIC50 MEAN

FEATURE deltaMEAN IC50

FEATURE IC50 effectSize

FEATURE neg Glass delta

FEATURE pos Glass delta

ANOVA FEATURE pval

Tissue ANOVA pval

MSI ANOVA pval

ANOVA FEATURE FDR %

a10

NRAS_mut

134

1

1

Etoposide

TOP2

7

19

2.77

0.114

2.92

2.8

2 *

2.1 **

1.7 *

2.47e-04

NA

3.59e-01

3

a25

TP53_mut

134

1

1

Etoposide

TOP2

13

13

2.77

-0.272

2.01

2.28

1.5 *

1.9 *

1.3 *

7.83e-04

NA

3.82e-01

3.8

All-tests volcano plot