ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:12 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual drug analysis: 1005


Drug details and screening numbers

Drug Name: Cisplatin
Drug ID: 1005
Synonyms: cis-Diammineplatinum(II) dichloride
Brand name: Cisplatin
Target: DNA crosslinker

Number of cell lines screened: 850
Screening concentration range(s): 0.0234375 to 6 uM and 0.0390625 to 10 uM


Statistically significant associations identified = 3

association id	FEATURE	Drug id	Propr	Public	Drug Name	Drug Target	N FEATURE pos	N FEATURE neg	log max Conc tested	FEATURE neg logIC50 MEAN	FEATURE pos logIC50 MEAN	FEATURE deltaMEAN IC50	FEATURE IC50 effectSize	FEATURE neg Glass delta	FEATURE pos Glass delta	ANOVA FEATURE pval	Tissue ANOVA pval	MSI ANOVA pval	ANOVA FEATURE FDR %
a413	loss_cnaPANCAN357_(ACVR2A)	1005	1	1	Cisplatin	DNA crosslinker	21	826	1.79, 2.30	2.86	3.7	0.836	0.7 .	0.7 .	0.72 .	4.98e-04	4.44e-17	5.52e-01	20
a485	gain_cnaPANCAN363_(ASXL1)	1005	1	1	Cisplatin	DNA crosslinker	85	762	1.79, 2.30	2.83	3.39	0.556	0.47	0.46	0.5 .	6.71e-04	4.6e-17	5.52e-01	23
a489	loss_cnaPANCAN255	1005	1	1	Cisplatin	DNA crosslinker	81	766	1.79, 2.30	2.85	3.23	0.381	0.32	0.32	0.29	6.93e-04	4.62e-17	5.52e-01	23

All-tests volcano plot