ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:55
iorio@ebi.ac.uk


Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual Feature analysis: gain_cnaPANCAN363_(ASXL1)


Feature details and cell panel numbers

Binary feature equal to 1 for samples having the genomic region(s) cnaPANCAN363_(ASXL1) amplified (see genomic region decoding file for further infos on this region)

Number of cell lines positive for this feature: 108


Statistically significant associations identified = 12
association id
FEATURE
Drug id
Propr
Public
Drug Name
Drug Target
N FEATURE pos
N FEATURE neg
log max Conc tested
FEATURE neg logIC50 MEAN
FEATURE pos logIC50 MEAN
FEATURE deltaMEAN IC50
FEATURE IC50 effectSize
FEATURE neg Glass delta
FEATURE pos Glass delta
ANOVA FEATURE pval
Tissue ANOVA pval
MSI ANOVA pval
ANOVA FEATURE FDR %
a161
gain_cnaPANCAN363_(ASXL1)
1017
1
1
Olaparib
PARP1, PARP2
85
762
1.61
3.47
4.09
0.615
0.61 .
0.59 .
0.78 .
5.05e-05
8.14e-21
2.23e-01
5.2
a195
gain_cnaPANCAN363_(ASXL1)
1529
1
1
MLN4924
NEDD8-activating enzyme
76
626
0
0.13
0.896
0.766
0.51 .
0.51 .
0.48
7.82e-05
1.04e-07
4.8e-02
6.6
a219
gain_cnaPANCAN363_(ASXL1)
1018
1
1
ABT-888
PARP1, PARP2
84
763
1.61
3.87
4.29
0.424
0.6 .
0.59 .
0.66 .
1.06e-04
8.57e-19
2.35e-01
7.9
a267
gain_cnaPANCAN363_(ASXL1)
1378
1
1
Bleomycin (50 uM)
DNA damage
101
831
3.91
2.26
2.87
0.609
0.29
0.29
0.31
1.79e-04
6.04e-31
3.34e-04
11
a276
gain_cnaPANCAN363_(ASXL1)
1003
1
1
Camptothecin
TOP1
85
761
-2.3
-4.14
-3.18
0.959
0.54 .
0.54 .
0.54 .
1.93e-04
2.88e-23
1.05e-01
12
a288
gain_cnaPANCAN363_(ASXL1)
208
1
1
SB-715992
KIF11
102
820
-2.06
-1.87
-1.01
0.861
0.49
0.48
0.52 .
2.13e-04
1.92e-33
1.9e-02
12
a333
gain_cnaPANCAN363_(ASXL1)
1495
1
1
AZD-2281
PARP1, PARP2
97
806
2.3
3.57
4
0.432
0.42
0.41
0.43
3.01e-04
8.5e-17
1.39e-03
15
a365
gain_cnaPANCAN363_(ASXL1)
300
1
1
CX-5461
RNA Pol I
99
818
2.33
2.88
3.95
1.07
0.54 .
0.53 .
0.66 .
3.69e-04
8.82e-45
2.24e-01
17
a386
gain_cnaPANCAN363_(ASXL1)
1239
1
1
YK 4-279
RNA helicase A
82
710
2.3
1.5
2.02
0.523
0.41
0.42
0.38
4.14e-04
1.4e-08
4.47e-02
18
a414
gain_cnaPANCAN363_(ASXL1)
179
1
1
5-Fluorouracil
DNA antimetabolite
99
814
3.47
3.47
4.35
0.884
0.5 .
0.49
0.6 .
5.01e-04
2.51e-45
2.32e-01
20
a441
gain_cnaPANCAN363_(ASXL1)
266
1
1
Zibotentan, ZD4054
Endothelin A Receptor
101
818
3
5.45
5.74
0.289
0.51 .
0.51 .
0.61 .
5.57e-04
1.73e-49
1.87e-01
21
a485
gain_cnaPANCAN363_(ASXL1)
1005
1
1
Cisplatin
DNA crosslinker
85
762
1.79, 2.30
2.83
3.39
0.556
0.47
0.46
0.5 .
6.71e-04
4.6e-17
5.52e-01
23


All-tests volcano plot