ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:08 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual drug analysis: 1017


Drug details and screening numbers

Drug Name: Olaparib
Drug ID: 1017
Synonyms: KU-0059436, AZD-2281
Brand name: Lynparza
Target: PARP1, PARP2

Number of cell lines screened: 850
Screening concentration range(s): 0.01953125 to 5 uM


Statistically significant associations identified = 2

association id

FEATURE

Drug id

Propr

Public

Drug Name

Drug Target

N FEATURE pos

N FEATURE neg

log max Conc tested

FEATURE neg logIC50 MEAN

FEATURE pos logIC50 MEAN

FEATURE deltaMEAN IC50

FEATURE IC50 effectSize

FEATURE neg Glass delta

FEATURE pos Glass delta

ANOVA FEATURE pval

Tissue ANOVA pval

MSI ANOVA pval

ANOVA FEATURE FDR %

a73

EWSR1-FLI1_mut

1017

1

1

Olaparib

PARP1, PARP2

16

831

1.61

3.56

2.03

-1.53

1.5 *

1.5 *

1.3 *

3.05e-06

5.44e-21

2.22e-01

0.68

a161

gain_cnaPANCAN363_(ASXL1)

1017

1

1

Olaparib

PARP1, PARP2

85

762

1.61

3.47

4.09

0.615

0.61 .

0.59 .

0.78 .

5.05e-05

8.14e-21

2.23e-01

5.2

All-tests volcano plot