ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:11 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual drug analysis: 266


Drug details and screening numbers

Drug Name: Zibotentan, ZD4054
Drug ID: 266
Synonyms:
Brand name:
Target: Endothelin A Receptor

Number of cell lines screened: 922
Screening concentration range(s): 0.078125 to 20 uM


Statistically significant associations identified = 4

association id	FEATURE	Drug id	Propr	Public	Drug Name	Drug Target	N FEATURE pos	N FEATURE neg	log max Conc tested	FEATURE neg logIC50 MEAN	FEATURE pos logIC50 MEAN	FEATURE deltaMEAN IC50	FEATURE IC50 effectSize	FEATURE neg Glass delta	FEATURE pos Glass delta	ANOVA FEATURE pval	Tissue ANOVA pval	MSI ANOVA pval	ANOVA FEATURE FDR %
a322	gain_cnaPANCAN84_(FGFR1,WHSC1L1)	266	1	1	Zibotentan, ZD4054	Endothelin A Receptor	68	851	3	5.46	5.8	0.348	0.62 .	0.61 .	0.73 .	2.89e-04	1.47e-49	1.86e-01	15
a325	gain_cnaPANCAN91_(MYC)	266	1	1	Zibotentan, ZD4054	Endothelin A Receptor	167	752	3	5.49	5.46	-0.025	0.044	0.045	0.039	2.95e-04	1.48e-49	1.86e-01	15
a441	gain_cnaPANCAN363_(ASXL1)	266	1	1	Zibotentan, ZD4054	Endothelin A Receptor	101	818	3	5.45	5.74	0.289	0.51 .	0.51 .	0.61 .	5.57e-04	1.73e-49	1.87e-01	21
a444	gain_cnaPANCAN90	266	1	1	Zibotentan, ZD4054	Endothelin A Receptor	86	833	3	5.49	5.44	-0.0462	0.081	0.083	0.07	5.68e-04	1.74e-49	1.87e-01	21

All-tests volcano plot