ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:02:20
iorio@ebi.ac.uk


Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual Feature analysis: gain_cnaPANCAN84_(FGFR1,WHSC1L1)


Feature details and cell panel numbers

Binary feature equal to 1 for samples having the genomic region(s) cnaPANCAN84_(FGFR1,WHSC1L1) amplified (see genomic region decoding file for further infos on this region)

Number of cell lines positive for this feature: 73


Statistically significant associations identified = 5
association id
FEATURE
Drug id
Propr
Public
Drug Name
Drug Target
N FEATURE pos
N FEATURE neg
log max Conc tested
FEATURE neg logIC50 MEAN
FEATURE pos logIC50 MEAN
FEATURE deltaMEAN IC50
FEATURE IC50 effectSize
FEATURE neg Glass delta
FEATURE pos Glass delta
ANOVA FEATURE pval
Tissue ANOVA pval
MSI ANOVA pval
ANOVA FEATURE FDR %
a322
gain_cnaPANCAN84_(FGFR1,WHSC1L1)
266
1
1
Zibotentan, ZD4054
Endothelin A Receptor
68
851
3
5.46
5.8
0.348
0.62 .
0.61 .
0.73 .
2.89e-04
1.47e-49
1.86e-01
15
a420
gain_cnaPANCAN84_(FGFR1,WHSC1L1)
178
1
1
BAY 61-3606
SYK
65
804
2.08
2.11
3.05
0.944
0.63 .
0.63 .
0.64 .
5.15e-04
1.46e-16
3.62e-03
20
a427
gain_cnaPANCAN84_(FGFR1,WHSC1L1)
207
1
1
AS601245
JNK
64
805
2.08
2.18
2.8
0.623
0.54 .
0.55 .
0.47
5.23e-04
4.19e-06
2.02e-02
20
a446
gain_cnaPANCAN84_(FGFR1,WHSC1L1)
133
1
1
Doxorubicin
DNA intercalating
65
807
0.0237
-1.82
-0.961
0.86
0.52 .
0.52 .
0.5
5.71e-04
5.28e-05
5.89e-02
21
a511
gain_cnaPANCAN84_(FGFR1,WHSC1L1)
194
1
1
AUY922
HSP90
65
798
-1.36
-2.97
-2.1
0.867
0.55 .
0.57 .
0.44
7.56e-04
5.68e-10
4.78e-02
24


All-tests volcano plot