ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:10 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual drug analysis: 133


Drug details and screening numbers

Drug Name: Doxorubicin
Drug ID: 133
Synonyms: Doxil,Rubex
Brand name: Adriamycin
Target: DNA intercalating

Number of cell lines screened: 875
Screening concentration range(s): 0.004 to 1.024 uM


Statistically significant associations identified = 3

association id	FEATURE	Drug id	Propr	Public	Drug Name	Drug Target	N FEATURE pos	N FEATURE neg	log max Conc tested	FEATURE neg logIC50 MEAN	FEATURE pos logIC50 MEAN	FEATURE deltaMEAN IC50	FEATURE IC50 effectSize	FEATURE neg Glass delta	FEATURE pos Glass delta	ANOVA FEATURE pval	Tissue ANOVA pval	MSI ANOVA pval	ANOVA FEATURE FDR %
a192	gain_cnaPANCAN411_(BLM,CRTC3,FANCI,IDH2,NR2F2,PCSK6)	133	1	1	Doxorubicin	DNA intercalating	26	846	0.0237	-1.79	-0.541	1.25	0.76 .	0.76 .	0.65 .	7.35e-05	4.82e-05	5.83e-02	6.3
a446	gain_cnaPANCAN84_(FGFR1,WHSC1L1)	133	1	1	Doxorubicin	DNA intercalating	65	807	0.0237	-1.82	-0.961	0.86	0.52 .	0.52 .	0.5	5.71e-04	5.28e-05	5.89e-02	21
a477	CHEK2_mut	133	1	1	Doxorubicin	DNA intercalating	5	867	0.0237	-1.77	0.852	2.62	1.6 *	1.6 *	1.2 *	6.48e-04	5.31e-05	5.89e-02	22

All-tests volcano plot