ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:07 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual drug analysis: 208


Drug details and screening numbers

Drug Name: SB-715992
Drug ID: 208
Synonyms: Ispinesib Mesylate
Brand name:
Target: KIF11

Number of cell lines screened: 925
Screening concentration range(s): 5e-04 to 0.128 uM


Statistically significant associations identified = 11

association id	FEATURE	Drug id	Propr	Public	Drug Name	Drug Target	N FEATURE pos	N FEATURE neg	log max Conc tested	FEATURE neg logIC50 MEAN	FEATURE pos logIC50 MEAN	FEATURE deltaMEAN IC50	FEATURE IC50 effectSize	FEATURE neg Glass delta	FEATURE pos Glass delta	ANOVA FEATURE pval	Tissue ANOVA pval	MSI ANOVA pval	ANOVA FEATURE FDR %
a56	EWSR1-FLI1_mut	208	1	1	SB-715992	KIF11	17	905	-2.06	-1.74	-3.42	-1.68	0.95 .	0.95 .	1 *	1.09e-06	6.99e-34	1.84e-02	0.32
a79	gain_cnaPANCAN366	208	1	1	SB-715992	KIF11	82	840	-2.06	-1.88	-0.686	1.19	0.68 .	0.67 .	0.81 .	4.03e-06	9e-34	1.85e-02	0.84
a84	loss_cnaPANCAN227, loss_cnaPANCAN228	208	1	1	SB-715992	KIF11	30	892	-2.06	-1.83	-0.13	1.7	0.97 .	0.96 .	1.2 *	5.19e-06	9.45e-34	1.86e-02	1
a106	loss_cnaPANCAN233	208	1	1	SB-715992	KIF11	48	874	-2.06	-1.84	-0.573	1.26	0.72 .	0.72 .	0.76 .	1.66e-05	1.18e-33	1.87e-02	2.6
a118	loss_cnaPANCAN229	208	1	1	SB-715992	KIF11	32	890	-2.06	-1.83	-0.242	1.58	0.9 .	0.9 .	1.1 *	1.93e-05	1.22e-33	1.87e-02	2.7
a138	loss_cnaPANCAN234	208	1	1	SB-715992	KIF11	45	877	-2.06	-1.83	-0.619	1.21	0.69 .	0.69 .	0.7 .	3.21e-05	1.34e-33	1.88e-02	3.8
a150	gain_cnaPANCAN364_(STK4)	208	1	1	SB-715992	KIF11	71	851	-2.06	-1.86	-0.726	1.13	0.64 .	0.64 .	0.77 .	3.83e-05	1.39e-33	1.88e-02	4.2
a181	loss_cnaPANCAN232	208	1	1	SB-715992	KIF11	45	877	-2.06	-1.83	-0.606	1.23	0.69 .	0.69 .	0.72 .	6.38e-05	1.53e-33	1.89e-02	5.8
a288	gain_cnaPANCAN363_(ASXL1)	208	1	1	SB-715992	KIF11	102	820	-2.06	-1.87	-1.01	0.861	0.49	0.48	0.52 .	2.13e-04	1.92e-33	1.9e-02	12
a347	gain_cnaPANCAN367_(ARFGAP1,GNAS)	208	1	1	SB-715992	KIF11	117	805	-2.06	-1.88	-1	0.882	0.5 .	0.49	0.56 .	3.43e-04	2.09e-33	1.91e-02	16
a447	loss_cnaPANCAN231	208	1	1	SB-715992	KIF11	49	873	-2.06	-1.83	-0.811	1.01	0.57 .	0.57 .	0.57 .	5.72e-04	2.3e-33	1.92e-02	21

All-tests volcano plot