ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:44 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual Feature analysis: loss_cnaPANCAN229


Feature details and cell panel numbers

Binary feature equal to 1 for samples having the genomic region(s) cnaPANCAN229 deleted (see genomic region decoding file for further infos on this region)

Number of cell lines positive for this feature: 34


Statistically significant associations identified = 7

association id	FEATURE	Drug id	Propr	Public	Drug Name	Drug Target	N FEATURE pos	N FEATURE neg	log max Conc tested	FEATURE neg logIC50 MEAN	FEATURE pos logIC50 MEAN	FEATURE deltaMEAN IC50	FEATURE IC50 effectSize	FEATURE neg Glass delta	FEATURE pos Glass delta	ANOVA FEATURE pval	Tissue ANOVA pval	MSI ANOVA pval	ANOVA FEATURE FDR %
a118	loss_cnaPANCAN229	208	1	1	SB-715992	KIF11	32	890	-2.06	-1.83	-0.242	1.58	0.9 .	0.9 .	1.1 *	1.93e-05	1.22e-33	1.87e-02	2.7
a204	loss_cnaPANCAN229	1175	1	1	AG-014699	PARP1, PARP2	33	885	1.61	3.39	4.16	0.77	0.79 .	0.78 .	1 *	9.06e-05	8.02e-15	1.23e-01	7.3
a205	loss_cnaPANCAN229	298	1	1	OSI-930	KIT, VEGFR, PDGFR	31	889	2.33	3.99	4.76	0.775	0.73 .	0.73 .	0.9 .	9.11e-05	1.59e-58	2.78e-01	7.3
a289	loss_cnaPANCAN229	1050	1	1	ZM-447439	AURKB	22	774	1.386, 0.693	2.19	3.4	1.21	0.97 .	0.96 .	1 *	2.16e-04	2.94e-12	2.75e-02	12
a305	loss_cnaPANCAN229	1239	1	1	YK 4-279	RNA helicase A	26	766	2.3	1.52	2.48	0.965	0.76 .	0.76 .	0.77 .	2.57e-04	1.35e-08	4.45e-02	14
a438	loss_cnaPANCAN229	1039	1	1	SL 0101-1	RSK, AURKB, PIM3	24	807	2.3	4.48	5.15	0.67	0.9 .	0.9 .	1.1 *	5.42e-04	1.83e-11	1.83e-01	20
a495	loss_cnaPANCAN229	1042	1	1	BIRB 0796	p38, JNK2	24	811	2.3	4.16	4.82	0.661	0.75 .	0.75 .	0.8 .	7.05e-04	5.56e-05	5.01e-01	23

All-tests volcano plot