ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:08 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual drug analysis: 298


Drug details and screening numbers

Drug Name: OSI-930
Drug ID: 298
Synonyms:
Brand name:
Target: KIT, VEGFR, PDGFR

Number of cell lines screened: 923
Screening concentration range(s): 0.04 to 10.24 uM


Statistically significant associations identified = 3

association id	FEATURE	Drug id	Propr	Public	Drug Name	Drug Target	N FEATURE pos	N FEATURE neg	log max Conc tested	FEATURE neg logIC50 MEAN	FEATURE pos logIC50 MEAN	FEATURE deltaMEAN IC50	FEATURE IC50 effectSize	FEATURE neg Glass delta	FEATURE pos Glass delta	ANOVA FEATURE pval	Tissue ANOVA pval	MSI ANOVA pval	ANOVA FEATURE FDR %
a78	EWSR1-FLI1_mut	298	1	1	OSI-930	KIT, VEGFR, PDGFR	17	903	2.33	4.03	3.11	-0.922	0.87 .	0.87 .	1.5 *	3.93e-06	6.38e-59	2.76e-01	0.83
a205	loss_cnaPANCAN229	298	1	1	OSI-930	KIT, VEGFR, PDGFR	31	889	2.33	3.99	4.76	0.775	0.73 .	0.73 .	0.9 .	9.11e-05	1.59e-58	2.78e-01	7.3
a343	loss_cnaPANCAN227, loss_cnaPANCAN228	298	1	1	OSI-930	KIT, VEGFR, PDGFR	29	891	2.33	3.99	4.74	0.752	0.71 .	0.71 .	0.85 .	3.35e-04	2.31e-58	2.78e-01	16

All-tests volcano plot