ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:38 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual Feature analysis: loss_cnaPANCAN234


Feature details and cell panel numbers

Binary feature equal to 1 for samples having the genomic region(s) cnaPANCAN234 deleted (see genomic region decoding file for further infos on this region)

Number of cell lines positive for this feature: 49


Statistically significant associations identified = 7

association id	FEATURE	Drug id	Propr	Public	Drug Name	Drug Target	N FEATURE pos	N FEATURE neg	log max Conc tested	FEATURE neg logIC50 MEAN	FEATURE pos logIC50 MEAN	FEATURE deltaMEAN IC50	FEATURE IC50 effectSize	FEATURE neg Glass delta	FEATURE pos Glass delta	ANOVA FEATURE pval	Tissue ANOVA pval	MSI ANOVA pval	ANOVA FEATURE FDR %
a88	loss_cnaPANCAN234	221	1	1	TAK-715	p38a	45	879	3.00, 2.33	4.13	4.96	0.833	0.71 .	0.71 .	0.75 .	6.37e-06	2.43e-54	2.3e-01	1.2
a138	loss_cnaPANCAN234	208	1	1	SB-715992	KIF11	45	877	-2.06	-1.83	-0.619	1.21	0.69 .	0.69 .	0.7 .	3.21e-05	1.34e-33	1.88e-02	3.8
a312	loss_cnaPANCAN234	255	1	1	CP724714	ERBB2	44	877	2.33	4.23	4.83	0.599	0.64 .	0.64 .	0.8 .	2.72e-04	2.44e-11	3.51e-01	14
a383	loss_cnaPANCAN234	1033	1	1	Vismodegib	SMO	42	805	2.3	4.36	4.89	0.532	0.61 .	0.61 .	0.62 .	4.05e-04	2.01e-25	4.45e-01	17
a463	loss_cnaPANCAN234	330	1	1	XMD13-2	RIPK	44	876	2.33	3.32	4.11	0.789	0.6 .	0.59 .	0.65 .	6.02e-04	6.72e-57	7.48e-01	21
a483	loss_cnaPANCAN234	1375	1	1	Temozolomide	DNA akylating agent	47	860	3.4	5.52	6.03	0.507	0.64 .	0.63 .	0.76 .	6.7e-04	3.6e-40	5.78e-01	23
a486	loss_cnaPANCAN234	200	1	1	LAQ824	HDAC	41	832	0.0237	-2.81	-2.08	0.727	0.6 .	0.61 .	0.45	6.82e-04	7.35e-14	8.73e-01	23

All-tests volcano plot