ANOVA PANCAN result package
Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:35 iorio@ebi.ac.uk
Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer
Individual Feature analysis: gain_cnaPANCAN366
Feature details and cell panel numbers
Binary feature equal to 1 for samples having the genomic region(s) cnaPANCAN366 amplified (see genomic region decoding file for further infos on this region)
Number of cell lines positive for this feature: 88
Statistically significant associations identified = 5
| association id |
FEATURE |
Drug id |
Propr |
Public |
Drug Name |
Drug Target |
N FEATURE pos |
N FEATURE neg |
log max Conc tested |
FEATURE neg logIC50 MEAN |
FEATURE pos logIC50 MEAN |
FEATURE deltaMEAN IC50 |
FEATURE IC50 effectSize |
FEATURE neg Glass delta |
FEATURE pos Glass delta |
ANOVA FEATURE pval |
Tissue ANOVA pval |
MSI ANOVA pval |
ANOVA FEATURE FDR % |
a79 |
gain_cnaPANCAN366 |
208 |
1 |
1 |
SB-715992 |
KIF11 |
82 |
840 |
-2.06 |
-1.88 |
-0.686 |
1.19 |
0.68 . |
0.67 . |
0.81 . |
4.03e-06 |
9e-34 |
1.85e-02 |
0.84 |
a222 |
gain_cnaPANCAN366 |
140 |
1 |
1 |
Vinorelbine |
Microtubules |
76 |
806 |
-2.75 |
-3.9 |
-3.1 |
0.799 |
0.49 |
0.5 |
0.47 |
1.14e-04 |
1.32e-06 |
9.36e-03 |
8.5 |
a320 |
gain_cnaPANCAN366 |
1378 |
1 |
1 |
Bleomycin (50 uM) |
DNA damage |
82 |
850 |
3.91 |
2.27 |
2.93 |
0.665 |
0.32 |
0.32 |
0.33 |
2.84e-04 |
6.55e-31 |
3.36e-04 |
15 |
a341 |
gain_cnaPANCAN366 |
1239 |
1 |
1 |
YK 4-279 |
RNA helicase A |
69 |
723 |
2.3 |
1.5 |
2.07 |
0.565 |
0.45 |
0.45 |
0.39 |
3.17e-04 |
1.37e-08 |
4.46e-02 |
15 |
a376 |
gain_cnaPANCAN366 |
257 |
1 |
1 |
NPK76-II-72-1 |
PLK3 |
81 |
838 |
2.33 |
2.76 |
3.84 |
1.08 |
0.64 . |
0.63 . |
0.8 . |
3.84e-04 |
3.07e-75 |
3.81e-02 |
17 |
All-tests volcano plot
