ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:08
iorio@ebi.ac.uk


Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual drug analysis: 300


Drug details and screening numbers

Drug Name: CX-5461
Drug ID: 300
Synonyms:
Brand name:
Target: RNA Pol I

Number of cell lines screened: 920
Screening concentration range(s): 0.04 to 10.24 uM


Statistically significant associations identified = 9
association id
FEATURE
Drug id
Propr
Public
Drug Name
Drug Target
N FEATURE pos
N FEATURE neg
log max Conc tested
FEATURE neg logIC50 MEAN
FEATURE pos logIC50 MEAN
FEATURE deltaMEAN IC50
FEATURE IC50 effectSize
FEATURE neg Glass delta
FEATURE pos Glass delta
ANOVA FEATURE pval
Tissue ANOVA pval
MSI ANOVA pval
ANOVA FEATURE FDR %
a92
loss_cnaPANCAN307_(CHD3,GPS2,TP53)
300
1
1
CX-5461
RNA Pol I
103
814
2.33
2.94
3.38
0.436
0.22
0.21
0.25
7.99e-06
3.55e-45
2.22e-01
1.4
a203
EWSR1-FLI1_mut
300
1
1
CX-5461
RNA Pol I
17
900
2.33
3.03
0.894
-2.14
1.1 *
1.1 *
1 *
8.99e-05
6.33e-45
2.24e-01
7.3
a209
MLL2_mut
300
1
1
CX-5461
RNA Pol I
96
821
2.33
3.1
2.07
-1.04
0.52 .
0.52 .
0.51 .
9.34e-05
6.38e-45
2.24e-01
7.4
a230
loss_cnaPANCAN304
300
1
1
CX-5461
RNA Pol I
73
844
2.33
2.97
3.27
0.301
0.15
0.15
0.17
1.23e-04
6.82e-45
2.24e-01
8.8
a278
loss_cnaPANCAN306
300
1
1
CX-5461
RNA Pol I
73
844
2.33
2.97
3.26
0.289
0.14
0.14
0.17
1.99e-04
7.63e-45
2.24e-01
12
a301
loss_cnaPANCAN305
300
1
1
CX-5461
RNA Pol I
73
844
2.33
2.97
3.24
0.269
0.13
0.13
0.16
2.44e-04
8e-45
2.24e-01
13
a303
gain_cnaPANCAN382_(FLT3,WASF3)
300
1
1
CX-5461
RNA Pol I
20
897
2.33
2.96
4.36
1.4
0.7 .
0.69 .
1.4 *
2.51e-04
8.06e-45
2.24e-01
14
a351
XRN1_mut
300
1
1
CX-5461
RNA Pol I
15
902
2.33
3.03
0.892
-2.14
1.1 *
1.1 *
1.1 *
3.5e-04
8.71e-45
2.24e-01
16
a365
gain_cnaPANCAN363_(ASXL1)
300
1
1
CX-5461
RNA Pol I
99
818
2.33
2.88
3.95
1.07
0.54 .
0.53 .
0.66 .
3.69e-04
8.82e-45
2.24e-01
17


All-tests volcano plot