| association id |
FEATURE |
Drug id |
Propr |
Public |
Drug Name |
Drug Target |
N FEATURE pos |
N FEATURE neg |
log max Conc tested |
FEATURE neg logIC50 MEAN |
FEATURE pos logIC50 MEAN |
FEATURE deltaMEAN IC50 |
FEATURE IC50 effectSize |
FEATURE neg Glass delta |
FEATURE pos Glass delta |
ANOVA FEATURE pval |
Tissue ANOVA pval |
MSI ANOVA pval |
ANOVA FEATURE FDR % |
a133 |
XRN1_mut |
1050 |
1 |
1 |
ZM-447439 |
AURKB |
13 |
783 |
1.386, 0.693 |
2.25 |
0.543 |
-1.71 |
1.4 * |
1.4 * |
1.4 * |
2.8e-05 |
2.4e-12 |
2.71e-02 |
3.5 |
a335 |
XRN1_mut |
5 |
1 |
1 |
Sunitinib |
PDGFRA, PDGFRB, KDR, KIT, FLT3 |
8 |
392 |
2.08 |
2.44 |
0.472 |
-1.97 |
1.2 * |
1.2 * |
0.74 . |
3.04e-04 |
1.38e-11 |
1.73e-01 |
15 |
a351 |
XRN1_mut |
300 |
1 |
1 |
CX-5461 |
RNA Pol I |
15 |
902 |
2.33 |
3.03 |
0.892 |
-2.14 |
1.1 * |
1.1 * |
1.1 * |
3.5e-04 |
8.71e-45 |
2.24e-01 |
16 |
a389 |
XRN1_mut |
199 |
1 |
1 |
Pazopanib |
VEGFR, PDGFRA, PDGFRB, KIT |
11 |
858 |
2.08 |
3.18 |
2.22 |
-0.967 |
0.74 . |
0.75 . |
0.38 |
4.25e-04 |
1.37e-13 |
4.46e-01 |
18 |
a500 |
XRN1_mut |
1021 |
1 |
1 |
Axitinib |
PDGFR, KIT, VEGFR |
13 |
831 |
0.693 |
1.98 |
0.973 |
-1 |
0.78 . |
0.8 . |
0.42 |
7.09e-04 |
3.99e-21 |
9.72e-01 |
23 |
a518 |
XRN1_mut |
222 |
1 |
1 |
BX-912 |
PDPK1 (PDK1) |
15 |
906 |
2.33 |
2.77 |
1.39 |
-1.38 |
0.77 . |
0.77 . |
0.61 . |
7.75e-04 |
5.83e-62 |
3.74e-01 |
25 |
