ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:06
iorio@ebi.ac.uk


Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual drug analysis: 1021


Drug details and screening numbers

Drug Name: Axitinib
Drug ID: 1021
Synonyms: AG-013736
Brand name: Axitinib
Target: PDGFR, KIT, VEGFR

Number of cell lines screened: 847
Screening concentration range(s): 0.0078125 to 2 uM


Statistically significant associations identified = 4
association id
FEATURE
Drug id
Propr
Public
Drug Name
Drug Target
N FEATURE pos
N FEATURE neg
log max Conc tested
FEATURE neg logIC50 MEAN
FEATURE pos logIC50 MEAN
FEATURE deltaMEAN IC50
FEATURE IC50 effectSize
FEATURE neg Glass delta
FEATURE pos Glass delta
ANOVA FEATURE pval
Tissue ANOVA pval
MSI ANOVA pval
ANOVA FEATURE FDR %
a19
BCR-ABL_mut
1021
1
1
Axitinib
PDGFR, KIT, VEGFR
6
838
0.693
1.99
-2.17
-4.16
3.4 **
3.3 **
11 **
3.37e-10
4.57e-22
9.72e-01
0.00029
a211
ASXL1_mut
1021
1
1
Axitinib
PDGFR, KIT, VEGFR
16
828
0.693
2
0.11
-1.89
1.5 *
1.5 *
0.94 .
9.45e-05
2.99e-21
9.72e-01
7.4
a270
loss_cnaPANCAN357_(ACVR2A)
1021
1
1
Axitinib
PDGFR, KIT, VEGFR
21
823
0.693
1.94
2.88
0.947
0.74 .
0.74 .
0.96 .
1.81e-04
3.28e-21
9.72e-01
11
a500
XRN1_mut
1021
1
1
Axitinib
PDGFR, KIT, VEGFR
13
831
0.693
1.98
0.973
-1
0.78 .
0.8 .
0.42
7.09e-04
3.99e-21
9.72e-01
23


All-tests volcano plot