ANOVA PANCAN result package
Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:33 iorio@ebi.ac.uk
Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer
Individual Feature analysis: MLL2_mut
Feature details and cell panel numbers
Binary feature equal to 1 for samples harboring mutations in MLL2
Number of cell lines positive for this feature: 107
Statistically significant associations identified = 21
| association id |
FEATURE |
Drug id |
Propr |
Public |
Drug Name |
Drug Target |
N FEATURE pos |
N FEATURE neg |
log max Conc tested |
FEATURE neg logIC50 MEAN |
FEATURE pos logIC50 MEAN |
FEATURE deltaMEAN IC50 |
FEATURE IC50 effectSize |
FEATURE neg Glass delta |
FEATURE pos Glass delta |
ANOVA FEATURE pval |
Tissue ANOVA pval |
MSI ANOVA pval |
ANOVA FEATURE FDR % |
a64 |
MLL2_mut |
295 |
1 |
1 |
NVP-BHG712 |
EPHB4 |
96 |
823 |
2.33 |
3.09 |
2.17 |
-0.914 |
0.56 . |
0.56 . |
0.52 . |
2.39e-06 |
5.25e-66 |
4.75e-01 |
0.6 |
a139 |
MLL2_mut |
275 |
1 |
1 |
I-BET |
BRD2, BRD3, BRD4 |
96 |
821 |
3 |
3.75 |
2.87 |
-0.882 |
0.51 . |
0.52 . |
0.47 |
3.25e-05 |
2.38e-89 |
7.65e-01 |
3.9 |
a166 |
MLL2_mut |
330 |
1 |
1 |
XMD13-2 |
RIPK |
97 |
823 |
2.33 |
3.44 |
2.67 |
-0.774 |
0.59 . |
0.59 . |
0.58 . |
5.28e-05 |
3.39e-57 |
7.47e-01 |
5.2 |
a185 |
MLL2_mut |
310 |
1 |
1 |
YM201636 |
FYV1 |
96 |
823 |
1.63 |
2.35 |
1.66 |
-0.686 |
0.55 . |
0.54 . |
0.57 . |
6.53e-05 |
1.52e-36 |
1.64e-02 |
5.8 |
a190 |
MLL2_mut |
257 |
1 |
1 |
NPK76-II-72-1 |
PLK3 |
96 |
823 |
2.33 |
2.97 |
1.92 |
-1.05 |
0.62 . |
0.62 . |
0.6 . |
7.25e-05 |
1.73e-75 |
3.78e-02 |
6.3 |
a194 |
MLL2_mut |
279 |
1 |
1 |
BIX02189 |
MAP2K5 (MEK5) |
96 |
823 |
3 |
4.33 |
3.74 |
-0.591 |
0.49 |
0.5 . |
0.45 |
7.54e-05 |
2.66e-71 |
4.72e-01 |
6.4 |
a202 |
MLL2_mut |
287 |
1 |
1 |
KIN001-244 |
PDPK1 (PDK1) |
95 |
823 |
3 |
3.34 |
2.74 |
-0.601 |
0.48 |
0.49 |
0.44 |
8.84e-05 |
2.26e-42 |
6.13e-01 |
7.2 |
a206 |
MLL2_mut |
260 |
1 |
1 |
NG-25 |
MAP3K7 (TAK1) |
96 |
823 |
2.33 |
2.72 |
1.9 |
-0.814 |
0.48 |
0.48 |
0.47 |
9.17e-05 |
8.26e-61 |
9.1e-01 |
7.3 |
a209 |
MLL2_mut |
300 |
1 |
1 |
CX-5461 |
RNA Pol I |
96 |
821 |
2.33 |
3.1 |
2.07 |
-1.04 |
0.52 . |
0.52 . |
0.51 . |
9.34e-05 |
6.38e-45 |
2.24e-01 |
7.4 |
a212 |
MLL2_mut |
305 |
1 |
1 |
TPCA-1 |
IKK |
96 |
823 |
3 |
3.09 |
2.21 |
-0.879 |
0.53 . |
0.53 . |
0.55 . |
9.45e-05 |
3.6e-62 |
7.83e-01 |
7.4 |
a227 |
MLL2_mut |
226 |
1 |
1 |
GSK1070916 |
AURKB |
92 |
802 |
0.94, 2.33 |
1.74 |
0.681 |
-1.06 |
0.5 |
0.51 . |
0.42 |
1.21e-04 |
7.7e-60 |
3.58e-01 |
8.8 |
a232 |
MLL2_mut |
346 |
1 |
1 |
THZ-2-102-1 |
CDK7 |
94 |
809 |
0.916, 2.996 |
-1.42 |
-2.68 |
-1.26 |
0.51 . |
0.5 |
0.61 . |
1.25e-04 |
8.7e-38 |
3.52e-01 |
8.8 |
a259 |
MLL2_mut |
333 |
1 |
1 |
T0901317 |
LXR |
96 |
818 |
2.33 |
4.39 |
3.76 |
-0.623 |
0.59 . |
0.64 . |
0.4 |
1.66e-04 |
1.25e-68 |
1.54e-01 |
11 |
a304 |
MLL2_mut |
225 |
1 |
1 |
Genentech Cpd 10 |
AURKA, AURKB |
97 |
826 |
2.33 |
2.58 |
1.8 |
-0.782 |
0.45 |
0.44 |
0.5 . |
2.52e-04 |
6.41e-42 |
3.09e-01 |
14 |
a317 |
MLL2_mut |
304 |
1 |
1 |
SB52334 |
ALK5 |
96 |
822 |
3 |
4.26 |
3.9 |
-0.354 |
0.28 |
0.28 |
0.29 |
2.82e-04 |
6.49e-23 |
5.26e-01 |
15 |
a329 |
MLL2_mut |
294 |
1 |
1 |
MPS-1-IN-1 |
MPS1 |
96 |
821 |
3 |
3.84 |
3.17 |
-0.672 |
0.49 |
0.48 |
0.58 . |
2.98e-04 |
2.78e-42 |
7.08e-01 |
15 |
a350 |
MLL2_mut |
1006 |
1 |
1 |
Cytarabine |
DNA synthesis |
88 |
755 |
0.693 |
0.263 |
-0.352 |
-0.614 |
0.37 |
0.37 |
0.35 |
3.5e-04 |
2.49e-16 |
5.98e-03 |
16 |
a457 |
MLL2_mut |
290 |
1 |
1 |
KIN001-260 |
IKK |
96 |
822 |
3 |
4.65 |
4.07 |
-0.581 |
0.49 |
0.49 |
0.5 . |
5.95e-04 |
5.85e-85 |
8.01e-01 |
21 |
a469 |
MLL2_mut |
328 |
1 |
1 |
SNX-2112 |
HSP90 |
95 |
816 |
0.94 |
-0.461 |
-1.56 |
-1.1 |
0.51 . |
0.51 . |
0.56 . |
6.13e-04 |
5.66e-43 |
1.76e-01 |
22 |
a494 |
MLL2_mut |
303 |
1 |
1 |
PIK-93 |
PI4K, PI3K |
96 |
823 |
3 |
2.75 |
1.96 |
-0.791 |
0.47 |
0.47 |
0.46 |
7e-04 |
2.96e-65 |
2.15e-01 |
23 |
a526 |
MLL2_mut |
222 |
1 |
1 |
BX-912 |
PDPK1 (PDK1) |
97 |
824 |
2.33 |
2.83 |
2.06 |
-0.768 |
0.43 |
0.43 |
0.43 |
7.9e-04 |
5.87e-62 |
3.74e-01 |
25 |
All-tests volcano plot
