ANOVA PANCAN result package
Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:08 iorio@ebi.ac.uk
Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer
Individual drug analysis: 290
Drug details and screening numbers
Drug Name: KIN001-260
Drug ID: 290
Synonyms: Bayer IKKb inhibitor
Brand name:
Target: IKK
Number of cell lines screened: 921
Screening concentration range(s): 0.078125 to 20 uM
Statistically significant associations identified = 5
| association id |
FEATURE |
Drug id |
Propr |
Public |
Drug Name |
Drug Target |
N FEATURE pos |
N FEATURE neg |
log max Conc tested |
FEATURE neg logIC50 MEAN |
FEATURE pos logIC50 MEAN |
FEATURE deltaMEAN IC50 |
FEATURE IC50 effectSize |
FEATURE neg Glass delta |
FEATURE pos Glass delta |
ANOVA FEATURE pval |
Tissue ANOVA pval |
MSI ANOVA pval |
ANOVA FEATURE FDR % |
a100 |
WNK1_mut |
290 |
1 |
1 |
KIN001-260 |
IKK |
10 |
908 |
3 |
4.6 |
3.58 |
-1.02 |
0.85 . |
0.85 . |
0.68 . |
1.27e-05 |
1.37e-85 |
8e-01 |
2.1 |
a146 |
loss_cnaPANCAN359_(CUL3) |
290 |
1 |
1 |
KIN001-260 |
IKK |
18 |
900 |
3 |
4.58 |
5.51 |
0.935 |
0.78 . |
0.77 . |
1.8 * |
3.61e-05 |
2.04e-85 |
8.01e-01 |
4.1 |
a198 |
EWSR1-FLI1_mut |
290 |
1 |
1 |
KIN001-260 |
IKK |
17 |
901 |
3 |
4.61 |
3.52 |
-1.09 |
0.91 . |
0.91 . |
1.2 * |
8.13e-05 |
2.77e-85 |
8.01e-01 |
6.8 |
a378 |
loss_cnaPANCAN360 |
290 |
1 |
1 |
KIN001-260 |
IKK |
25 |
893 |
3 |
4.58 |
5.19 |
0.61 |
0.51 . |
0.5 . |
0.76 . |
3.9e-04 |
5e-85 |
8.01e-01 |
17 |
a457 |
MLL2_mut |
290 |
1 |
1 |
KIN001-260 |
IKK |
96 |
822 |
3 |
4.65 |
4.07 |
-0.581 |
0.49 |
0.49 |
0.5 . |
5.95e-04 |
5.85e-85 |
8.01e-01 |
21 |
All-tests volcano plot
