ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:58 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual Feature analysis: loss_cnaPANCAN360


Feature details and cell panel numbers

Binary feature equal to 1 for samples having the genomic region(s) cnaPANCAN360 deleted (see genomic region decoding file for further infos on this region)

Number of cell lines positive for this feature: 30


Statistically significant associations identified = 7

association id	FEATURE	Drug id	Propr	Public	Drug Name	Drug Target	N FEATURE pos	N FEATURE neg	log max Conc tested	FEATURE neg logIC50 MEAN	FEATURE pos logIC50 MEAN	FEATURE deltaMEAN IC50	FEATURE IC50 effectSize	FEATURE neg Glass delta	FEATURE pos Glass delta	ANOVA FEATURE pval	Tissue ANOVA pval	MSI ANOVA pval	ANOVA FEATURE FDR %
a189	loss_cnaPANCAN360	1259	1	1	BMN-673	PARP1	27	885	2.3	2.07	3.33	1.25	0.67 .	0.66 .	1.3 *	7.04e-05	1.86e-18	2.17e-03	6.1
a243	loss_cnaPANCAN360	310	1	1	YM201636	FYV1	25	894	1.63	2.26	3.03	0.771	0.61 .	0.61 .	0.79 .	1.45e-04	1.78e-36	1.65e-02	9.8
a373	loss_cnaPANCAN360	287	1	1	KIN001-244	PDPK1 (PDK1)	25	893	3	3.26	4.02	0.76	0.6 .	0.6 .	0.62 .	3.83e-04	3.15e-42	6.14e-01	17
a375	loss_cnaPANCAN360	136	1	1	Mitomycin C	DNA crosslinker	25	848	2.77	-0.776	0.407	1.18	0.75 .	0.75 .	0.71 .	3.84e-04	1.07e-05	1.15e-01	17
a378	loss_cnaPANCAN360	290	1	1	KIN001-260	IKK	25	893	3	4.58	5.19	0.61	0.51 .	0.5 .	0.76 .	3.9e-04	5e-85	8.01e-01	17
a388	loss_cnaPANCAN360	345	1	1	KIN001-270	CDK9	25	894	3	4.86	5.39	0.53	0.58 .	0.58 .	0.64 .	4.25e-04	5.88e-57	5.38e-02	18
a416	loss_cnaPANCAN360	179	1	1	5-Fluorouracil	DNA antimetabolite	26	887	3.47	3.53	4.62	1.09	0.61 .	0.61 .	0.77 .	5.08e-04	2.52e-45	2.32e-01	20

All-tests volcano plot