ANOVA PANCAN result package

Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:08 iorio@ebi.ac.uk

Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer


Individual drug analysis: 345


Drug details and screening numbers

Drug Name: KIN001-270
Drug ID: 345
Synonyms:
Brand name:
Target: CDK9

Number of cell lines screened: 922
Screening concentration range(s): 0.078125 to 20 uM


Statistically significant associations identified = 4

association id	FEATURE	Drug id	Propr	Public	Drug Name	Drug Target	N FEATURE pos	N FEATURE neg	log max Conc tested	FEATURE neg logIC50 MEAN	FEATURE pos logIC50 MEAN	FEATURE deltaMEAN IC50	FEATURE IC50 effectSize	FEATURE neg Glass delta	FEATURE pos Glass delta	ANOVA FEATURE pval	Tissue ANOVA pval	MSI ANOVA pval	ANOVA FEATURE FDR %
a77	EWSR1-FLI1_mut	345	1	1	KIN001-270	CDK9	17	902	3	4.89	4.15	-0.738	0.81 .	0.81 .	0.92 .	3.81e-06	1.54e-57	5.26e-02	0.82
a188	WNK1_mut	345	1	1	KIN001-270	CDK9	10	909	3	4.89	3.97	-0.917	1 *	1 *	1.4 *	6.96e-05	3.53e-57	5.34e-02	6.1
a388	loss_cnaPANCAN360	345	1	1	KIN001-270	CDK9	25	894	3	4.86	5.39	0.53	0.58 .	0.58 .	0.64 .	4.25e-04	5.88e-57	5.38e-02	18
a491	NFE2L2_mut	345	1	1	KIN001-270	CDK9	14	905	3	4.86	5.77	0.911	1 .	0.99 .	1.6 *	6.94e-04	6.74e-57	5.39e-02	23

All-tests volcano plot