ANOVA PANCAN result package
Francesco Iorio, EMBL - European Bioinformatics Institute
result parsing started on 2016-03-31 19:01:45 iorio@ebi.ac.uk
Drug Domain: GDSC1000_paper_set, Analysis Domain: panCancer
Individual Feature analysis: loss_cnaPANCAN305
Feature details and cell panel numbers
Binary feature equal to 1 for samples having the genomic region(s) cnaPANCAN305 deleted (see genomic region decoding file for further infos on this region)
Number of cell lines positive for this feature: 83
Statistically significant associations identified = 6
| association id |
FEATURE |
Drug id |
Propr |
Public |
Drug Name |
Drug Target |
N FEATURE pos |
N FEATURE neg |
log max Conc tested |
FEATURE neg logIC50 MEAN |
FEATURE pos logIC50 MEAN |
FEATURE deltaMEAN IC50 |
FEATURE IC50 effectSize |
FEATURE neg Glass delta |
FEATURE pos Glass delta |
ANOVA FEATURE pval |
Tissue ANOVA pval |
MSI ANOVA pval |
ANOVA FEATURE FDR % |
a126 |
loss_cnaPANCAN305 |
1047 |
1 |
1 |
Nutlin-3a |
MDM2 |
69 |
777 |
2.08, 1.39 |
3.5 |
3.85 |
0.347 |
0.26 |
0.25 |
0.31 |
2.22e-05 |
5.81e-32 |
6.3e-02 |
2.9 |
a175 |
loss_cnaPANCAN305 |
110 |
1 |
1 |
Roscovitine |
CDKs |
43 |
354 |
2.77 |
3.87 |
4.36 |
0.485 |
0.5 . |
0.5 . |
0.51 . |
6.01e-05 |
1.8e-04 |
8.98e-01 |
5.6 |
a301 |
loss_cnaPANCAN305 |
300 |
1 |
1 |
CX-5461 |
RNA Pol I |
73 |
844 |
2.33 |
2.97 |
3.24 |
0.269 |
0.13 |
0.13 |
0.16 |
2.44e-04 |
8e-45 |
2.24e-01 |
13 |
a315 |
loss_cnaPANCAN305 |
1378 |
1 |
1 |
Bleomycin (50 uM) |
DNA damage |
76 |
856 |
3.91 |
2.24 |
3.29 |
1.05 |
0.51 . |
0.5 . |
0.61 . |
2.8e-04 |
6.53e-31 |
3.36e-04 |
15 |
a395 |
loss_cnaPANCAN305 |
1175 |
1 |
1 |
AG-014699 |
PARP1, PARP2 |
70 |
848 |
1.61 |
3.39 |
3.77 |
0.377 |
0.38 |
0.38 |
0.45 |
4.44e-04 |
9.4e-15 |
1.24e-01 |
19 |
a406 |
loss_cnaPANCAN305 |
179 |
1 |
1 |
5-Fluorouracil |
DNA antimetabolite |
73 |
840 |
3.47 |
3.55 |
3.74 |
0.199 |
0.11 |
0.11 |
0.11 |
4.84e-04 |
2.49e-45 |
2.32e-01 |
20 |
All-tests volcano plot
